神经系统的发育机制与相关疾病机理。重点关注方向：1）泛素化修饰等蛋白稳态调控机制对神经系统细胞分化与功能的调控作用；2）上述调控机制在脑发育障碍与神经退行性疾病中的病理作用；3）相关疾病动物模型的构建及治疗干预策略开发。

1.国家重点研发计划项目,非人灵长类与树鼩脑疾病模型创建与关键技术研究（2021-2024）, 主持。

2.云南省“兴滇英才支持计划”云岭学者项目，神经发育/退行性疾病机理及灵长类动物模型的创制与应用（2024-2029），主持。

近5年内发表的代表性论文/专著

1. Lu T, Ma P, Fang H, Chen A, Kuang X, Wang M, Su L, Wang S, Zhang Y, Wang J, Yang B, Shi D-L, Zhou Y, Gong Q, Liu X*, Mao B*, Shao M* (2025). Prkra dimer senses double-stranded RNAs to dictate global translation efficiency. Mol. Cell, 85, 1–16.

2. Li Y, Wan LP, Song NN, Ding YQ, Zhao S, Niu J, Mao B*, Sheng N*, Ma P*. (2024) RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination. Sci. Adv. 10: eadk3931.

3. Wang H#, Liu X#, Liu Y, Yang C, Ye Y, Yu X, Sheng N, Zhang S*, Mao B*, Ma P*. (2024) The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability. eLife 13:RP94657.

4. Ma P#, Wan LP#, Li Y#, He CH#, Song NN, Zhao S, Wang H, Ding YQ*, Mao B* and Sheng N*. (2022)   RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission，Science Advances, 8：eabq4736.

5. Guo X# , Ma P# , Li Y , Yang Y , Wang C, Xu T, Wang H, Li C, Mao B*,  Qi X* . (2021). Rnf220 mediates K63-linked polyubiquitination of Stat1 and promotes host defense. Cell Death Diff. 28:640-656.

其他代表性论文/专著

1. Ma P#, Song NN#, Li Y#, Zhang Q, Zhang L, Zhang L, Kong Q, Ma L, Yang X, Ren B, Li C, Zhao X, Li Y, Xu Y, Gao X*, Ding YQ*, Mao B*. (2019) Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. Cell Reports, 28:541–553.

2. Ma P#, An T#, Zhu L, Zhang L, Wang H, Ren B, Sun B, Zhou X, Li Y*, Mao B*. (2020) RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling. Development 147: dev188078.

3. Ma P#, Song NN#, Cheng X#, Zhu L, Zhang Q, Zhang L, Yang X, Wang H, Kong Q, Shi D*, Ding YQ*, Mao B*. (2020) ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling. J Mol Cell Biol. 12:337-344

4. Song NN#, Ma P#, Zhang Q, Zhang L, Wang H, Zhang L, Zhu L, He CH, Mao B*, DingYQ*. (2020) Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. Development, 147: dev185199.

5.Ma P#, Liu XY#, Xu ZX #, Liu HM #, Ding XN#, Huang Z#, Shi CG, Liang LC, Xu LH, Li XL, Li GM, He YQ, Ding ZL, Chai CC, Wang HY, Qiu JY, Zhu JC, Wang XL, Ding PW, Zhou S, Yuan YT, Wu WD, Wan C, Yan YN, Zhou YT, Zhou QJ, Wang GD, Zhang QJ*, Xu X*, Li G*, Zhang SH*, Mao B*, Chen DS*. (2022) Joint profiling of gene expression and chromatin accessibility of amphioxus development at single cell resolution. Cell Reports，39:110979

细胞生物学学会发育生物学分会委员