李明，博士，研究员，博士生导师，昆明动物所副所长。2008年毕业于武汉大学生命科学学院，获学士学位；2013年于中国科学院昆明动物研究所获遗传学博士学位，同年赴美国约翰霍普金斯大学医学院从事博士后研究。2016年回国后，在昆明动物研究所组建生物精神病学学科组，致力于精神疾病的遗传与神经机制研究。现任中国神经科学学会理事（2023-）、精神病学基础与临床分会委员（2020-），中国遗传学会行为遗传学分会委员（2023-），云南省神经科学学会常委（2022-）。获国家自然科学基金委青年科学基金项目A类（2022）、B类（2017）、国家海外高层次青年人才项目（2017）和云岭学者项目（2023）资助。现任BMC Medicine期刊编委（2022-）、Biological Psychiatry期刊编委（2025-）。在Nature Medicine、JAMA Psychiatry、Nature Communications、Molecular Psychiatry、American Journal of Psychiatry、Biological Psychiatry、Science Bulletin等期刊发表论文，系统揭示了双相障碍等精神疾病的分子机制、细胞病理及生理表型，为我国精神疾病的精准防控提供了重要的科学依据和理论支撑。

1.    Yang ZH, Cai X, Zhang CY, Zhang Q, Li M, Ding ZL, Guo Y, Ma G, Yang CH, Guo L, Chang H, Wang C, Li M, Xiao X. NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice. Nature Communications 2024;15:9180.

2.    Zhou DY, Su X, Wu Y, Yang Y, Zhang L, Cheng S, Shao M, Li W, Zhang Z, Wang L, Lv L, Li M, Song M. Decreased CNNM2 expression in prefrontal cortex affects sensorimotor gating function, cognition, dendritic spine morphogenesis and risk of schizophrenia. Neuropsychopharmacology 2024;49:433-442.

3.    Yin MY, Guo L, Zhao LJ, Zhang C, Liu WP, Zhang CY, Huo JH, Wang L, Li SW, Zheng CB, Xiao X, Li M, Wang C, Chang H. Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice. BMC Medicine 2023;21:256.

4.    Qi HX, Xiao X, Li T, Li M. New "drugs and targets" in the GWAS era of bipolar disorder. Bipolar Disorders 2023;25(5):410-421.

5.    Shang MY, Wu Y, Zhang CY, Qi HX, Zhang Q, Huo JH, Wang L, Wang C, Li M. Bidirectional genetic overlap between bipolar disorder and intelligence. BMC Medicine 2022;20:464.

6.    Li M, Li T, Xiao X, Chen J, Hu Z, Fang Y. Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings. Molecular Psychiatry 2022;27:2927-2939.

7.    Xiao X, Zhang CY, Zhang Z, Hu Z, Li M, Li T. Revisiting tandem repeats in psychiatric disorders from perspectives of genetics, physiology, and brain evolution. Molecular Psychiatry 2022;27:466-475.

8.    Zhang CY, Xiao X, Zhang Z, Hu Z, Li M. An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data. Molecular Psychiatry 2022;27:95-112.

9.    Chen R, Yang Z, Liu J, Cai X, Huo Y, Zhang Z, Li M, Chang H, Luo XJ. Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants. Genome Medicine 2022;14:53.

10.  Li HJ, Zhang C, Hui L, Zhou DS, Li Y, Zhang CY, Wang C, Wang L, Li W, Yang Y, Qu N, Tang J, He Y, Zhou J, Yang Z, Li X, Cai J, Yang L, Chen J, Fan W, Tang W, Tang W, Jia QF, Liu W, Zhuo C, Song X, Liu F, Bai Y, Zhong BL, Zhang SF, Chen J, Xia B, Lv L, Liu Z, Hu S, Li XY, Liu JW, Cai X, Yao YG, Zhang Y, Yan H, Chang S, Zhao JP, Yue WH, Luo XJ, Chen X, Xiao X, Fang Y, Li M, for the GeseDNA Research Team. Novel risk loci associated with genetic risk for bipolar disorder among Han Chinese individuals: A genome-wide association study and meta-analysis. JAMA Psychiatry 2021;78:320-330.

11.  Chang H, Cai X, Li HJ, Liu WP, Zhao LJ, Zhang CY, Wang JY, Liu JW, Ma XL, Wang L, Yao YG, Luo XJ, Li M, Xiao X. Functional genomics identify a regulatory risk variation rs4420550 in the 16p11.2 schizophrenia-associated locus. Biological Psychiatry 2021;89:246-255.

12.  Chang H, Cai X, Yang ZH, Xiao X, Li M. Regulation of TRANK1 by GSK-3 in the brain: unexpected interactions. Molecular Psychiatry 2021;26:6109-6111.

13.  Zhang C, Xiao X, Li T, Li M. Translational genomics and beyond in bipolar disorder. Molecular Psychiatry 2021;26:186-202.

14.  Cao X, Liu WP, Cheng L, Li HJ, Wu H, Liu Y, Chen C, Xiao X, Li M, Wang GD, Zhang YP. Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs. Science Bulletin 2021;66:187-196.

15.  Cai X, Yang ZH, Li HJ, Xiao X, Li M, Chang H. A human-specific schizophrenia risk tandem repeat affects alternative splicing of a human-unique isoform AS3MT^d2d3 and mushroom dendritic spine density. Schizophrenia Bulletin 2021;41:219-227.

16.  Li W, Cai X, Li HJ, Song M, Zhang CY, Yang Y, Zhang L, Zhao L, Liu W, Wang L, Shao M, Zhang Y, Zhang C, Cai J, Zhou DS, Li X, Hui L, Jia QF, Qu N, Zhong BL, Zhang SF, Chen J, Xia B, Li Y, Song X, Fan W, Tang W, Tang W, Tang J, Chen X, Yue W, Zhang D, Fang Y, Xiao X, Li M, Lv L, Chang H. Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder. Neuropsychopharmacology 2021;46:1103-1112.

17.  Yang Z, Zhou D, Li H, Cai X, Liu W, Wang L, Chang H, Li M, Xiao X. The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function and mushroom dendritic spine. Molecular Psychiatry 2020;25:48-66.

18.  Li H, Zhang C, Cai X, Wang L, Luo F, Ma Y, Li M, Xiao X. Genome-wide association study of creativity reveals genetic overlap with psychiatric disorders, risk tolerance, and risky behaviors. Schizophrenia Bulletin 2020;46:1317-1326.

19.  Liu W, Li W, Cai X, Yang Z, Li H, Su X, Song M, Zhou DS, Li X, Zhang C, Shao M, Zhang L, Yang Y, Zhang Y, Zhao J, Chang H, Yao YG, Fang Y, Lv L, Li M, Xiao X. Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci. Neuropsychopharmacology 2020;45:1196-1206.

20.  Li HJ, Su X, Zhang L, Zhang CY, Wang L, Li W, Yang Y, Lv L, Li M, Xiao X. Transcriptomic analyses of humans and mice provide insights into depression. Zoological Research 2020;41:632-643.

21.  Yang ZH, Cai X, Qu N, Zhao LJ, Zhong BL, Zhang SF, Chen J, Xia B, Jiang HY, Zhou DY, Liu WP, Chang H, Xiao X, Li Y, Li M. Identification of a functional 339 bp Alu insertion polymorphism in the schizophrenia-associated locus at 10q24.32. Zoological Research 2020;41:84-89.