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王明山   研究员
进化与生物多样性基因组学学科组
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电子邮件: wangmingshan@mail.kiz.ac.cn
通讯地址: 云南省昆明市盘龙区龙欣路17号, 401/402室    650201
其他主页: https://www.researchgate.net/profile/Ming-Shan-Wang
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  简  历

王明山,理学博士,博士生导师,中科院青年创新促进会会员。2011年毕业于吉林大学,获得农学学士学位;2017年毕业于中科院昆明动物研究所,获得理学博士学位;2017-2019年在中科院昆明动物研究所工作,担任副(破格)研究员;2019-2022年在美国霍华德休斯医学研究所(HHMI),加州大学圣克鲁兹分校做博士后研究;20229月作为高层次人才引进中科院昆明动物研究所,组建进化与生物多样性基因组学学科组,担任PI。主持和参加过多项国家级和中科院项目,在Nature GeneticsNature Ecology & EvolutionCell ResearchMolecular Biology and EvolutionNational Science ReviewBMC Biology等期刊共发表30余篇论文。获得中科院院长特别奖、中科院百篇优秀博士学位论文和云南省自然科学奖一等奖(排名第三)等奖励。

  研究方向

1. 基因组学与动物多样性保护

利用生物信息学、基因组学和古基因组学等手段探究我国西南和周边地域生物多样性形成和维持机制;阐明种群分化的遗传驱动力和分子机制;揭示不同动物类群对特定环境和气候变化响应的对策和适应性进化的遗传基础;探讨濒危类群的种群健康程度和遗传潜力。针对濒危原因,提出科学有效的保护措施,促进生物多样性资源的保护和综合开发利用。

2. 复杂性状形成和演化的遗传机制

采用多组学、生物信息学、基因编辑等交叉学科手段开展鸟类复杂性状形成和演化机制的研究,包括鸟类飞行能力的起源、进化发育以及空间定位和认知能力等形成机制。研究成果将服务于动物复杂性状、人类高级认知功能和神经系统发育、形成和进化机制的解析,以及神经系统相关疾病的诊治和优质高效畜禽品种的培育。

  承担科研项目
  专家类别
研究员
  社会任职
  获奖及荣誉
  代表论著

1). Ming-Shan Wang, Yan Li, Min-Sheng Peng, Li Zhong, Zong-Ji Wang, Qi-Ye Li, Xiao-Long Tu, Yang Dong, Chun-Ling Zhu, Lu Wang, Min-Min Yang, Shi-Fang Wu, Yong-Wang Miao, Jian-Ping Liu, David M Irwin, Wen Wang, Dong-Dong Wu, Ya-Ping Zhang. 2015. Genomic analyses reveal potential independent adaptation to high altitude in Tibetan chicken. Molecular Biology and Evolution 32(7): 1880-9.

2). Ming-Shan Wang, Rong-Wei Zhang, Ling-Yan Su, Yan Li, Min-Sheng Peng, He-Qun Liu, Lin Zeng, David M Irwin, Jiu-Lin Du, Yong-Gang Yao, Dong-Dong Wu, Ya-Ping Zhang. 2016. Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication. Cell Research 26(5): 556-573.

3). Ming-Shan Wang, Yong-Xia Huo, Yan Li, Newton O. Otecko, Ling-Yan Su, Shi-Fang Wu, Min-Sheng Peng, He-Qun Liu, Lin Zeng, David M Irwin, Yong-Gang Yao, Dong-Dong Wu, Ya-Ping Zhang. 2016. Comparative population genomics reveal genetic basis underlying body size of domestic chickens. Journal of Molecular Cell Biology 8(6): 542-52. [Cover story]

4). Ming-Shan Wang, He-Chuan Yang, Yan Li, Dong-Dong Wu, Ya-Ping Zhang. 2016. Olfactory genes in Tibetan wild boar. Nature Genetics 48(9): 972-3.

5). Ming-Shan Wang, Newton O. Otecko , Sheng Wang, Dong-Dong Wu, Min-Min Yang, Yi-Long Xu, Robert W. Murphy, Min-Sheng Peng, and Ya-Ping Zhang. 2017. An Evolutionary Genomic Perspective on the Breeding of Dwarf Chickens. Molecular Biology and Evolution 34(12):3081-3088.

6). Ming-Shan Wang, Yan Zeng, Xiao Wang, Wen-Hui Nie, Jin-Huan Wang, Wei-Ting Su,Newton O. Otecko, Zi-Jun Xiong, Sheng Wang, Kai-Xing Qu, Shou-Qing Yan, Min-Min Yang, Wen Wang, Yang Dong, Dong-Dong Wu, Ya-Ping Zhang. 2017. Draft genome of the gayal. Bos frontalis. GigaScience 6(11):1-7.

7). Ming-Shan Wang, Adeniyi C. Adeola, Yan Li, Ya-Ping Zhang, Dong-Dong Wu. 2015. Accelerated evolving constraint elements for Haematophagic Adaptation of Mosquito. Zoological Research 36 (6): 320-327.

8). Xing Guo, Yan-Qing Li, Ming-Shan Wang (co-1st), Zhi-Bin Wang, Quan Zhang, Yong Shao, Run-Shen Jiang, Sheng Wang, Chen-Dong Ma, Robert W. Murphy, Guang-Qin Wang, Jing Dong, Li Zhang, Dong-Dong Wu, Bing-Wang Du, Min-Sheng Peng, and Ya-Ping Zhang. A parallel mechanism underlying frizzle in domestic chickens. Journal of Molecular Cell Biology, 10:589-591.

9). Dong-Dong Wu, Cui-Ping Yang, Ming-Shan Wang (co-1st), Kun-Zhe Dong, Da-Wei Yan, Zi-Qian Hao, Song-Qing Fan, Shu-Zhou Chu, Qiu-Shuo Shen, Li-Ping Jiang, Yan Li, Lin Zeng, He-Qun Liu, Hai-Bing Xie, Yun-Fei Ma, Xiao-Yan Kong, Shu-Li Yang, Xin-Xing Dong, Ali Esmailizadeh Koshkoiyeh, David M Irwin, Xiao Xiao, Ming Li, Yang Dong, Wen Wang, Peng Shi, Hai-Peng Li, Yue-Hui Ma, Xiao Gou,Yong-Bin Chen, Ya-Ping Zhang. 2020. Convergent genomic signatures of high altitude adaptation among domestic mammals. National Science Review, 7(11)952–963.

10). Ming-Shan Wang, Mukesh Thakur, Min-Sheng Peng, Yu Jiang, Laurent Alain Fran?ois Frantz, Ming Li, Jin-Jin Zhang, Sheng Wang, Joris Peters, Newton Otieno Otecko, Chatmongkon Suwannapoom, Xing Guo, Zhu-Qing Zheng, Ali Esmailizadeh, Nalini Yasoda Hirimuthugoda, Hidayat Ashari, Sri Suladari, Moch Syamsul Arifin Zein, Szilvia Kusza, Saeed Sohrabi, Hamed Kharrati-Koopaee, Quan-Kuan Shen, Lin Zeng, Min-Min Yang, Ya-Jiang Wu, Xing-Yan Yang, Xue-Mei Lu, Xin-Zheng Jia, Qing-Hua Nie, Susan Joy Lamont, Emiliano Lasagna, Simone Ceccobelli, Humpita Gamaralalage Thilini Nisanka Gunwardana, Thilina Madusanka Senasige, Shao-Hong Feng, Jing-Fang Si, Hao Zhang, Jie-Qiong Jin, Ming-Li Li, Yan-Hu Liu, Hong-Man Chen, Cheng Ma, Shan-Shan Dai, Abul Kashem Fazlul Haque Bhuiyan, Muhammad Sajjad Khan, Gamamada Liyanage Lalanie Pradeepa Silva, Thi-Thuy Le, Okeyo Ally Mwai, Mohamed Nawaz Mohamed Ibrahim, Megan Supple, Beth Shapiro, Olivier Hanotte, Guojie Zhang, Greger Larson, Jian-Lin Han, Dong-Dong Wu & Ya-Ping Zhang. 2020. 863 genomes reveal the origin and domestication of chicken. Cell Research, 30,693-701) [cover story].

11). Ming-Shan Wang, Sheng Wang, Yan Li, Yadvendradev Jhala, Mukesh Thakur, Newton O Otecko, Jing-Fang Si, Hong-Man Chen, Beth Shapiro, Rasmus Nielsen, Ya-Ping Zhang, Dong-Dong Wu. Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids.2020. Molecular Biology and Evolution, 37(9): 2616–2629 [cover story].

12). Xing Guo, Zhi-Cheng Wang, Sheng Wang, Hui-Fang Li, Chatmongkon Suwannapoom, Jiang-Xian Wang, Cheng Zhang, Yong Shao, Ming-Shan Wang (co-corresponding author), and Run-Shen Jiang*. 2020. Genetic signature of hybridization between Chinese spot-billed ducks and domesticated ducks. Animal Genetics, 51(6):866-875.

13). Xing Guo, Xin-Xin He, Hong Chen, Zhi-Cheng Wang, Hui-Fang Li, Jiang-Xian Wang, Ming-Shan Wang (co-corresponding author), Run-Shen Jiang. 2021. Revisiting the evolutionary history of domestic and wild ducks based on genomic analyses. Zoological Research, 42(1): 43-50.

14). Yun-Mei Wang, Saber Khederzadeh, Shi-Rong Li, Newton Otieno Otecko, David M. Irwin, Mukesh Thakur, Xiao-Die Ren, Ming-Shan Wang (co-corresponding author), Dong-Dong Wu, Ya-Ping Zhang. 2021. Integrating Genomic and Transcriptomic Data to Reveal Genetic Mechanisms Underlying Piao Chicken Rumpless Trait. Genomics, Proteomics & Bioinformatics, 19(5):787-799.

15). Ming-Shan Wang, Jin-Jin Zhang, Xing Guo, Ming Li, Rachel Meyer, Hidayat Ashari, Zhu-Qing Zheng, Sheng Wang, Min-Sheng Peng, Yu Jiang, Mukesh Thakur, Chatmongkon Suwannapoom, Ali Esmailizadeh, Nalini Yasoda Hirimuthugoda, Moch Syamsul Arifin Zein, Szilvia Kusza, Hamed Kharrati-Koopaee, Lin Zeng, Yun-Mei Wang, Ting-Ting Yin, Min-Min Yang, Ming-Li Li, Xue-Mei Lu, Emiliano Lasagna, Simone Ceccobelli, Humpita Gamaralalage Thilini Nisanka Gunwardana, Thilina Madusanka Senasig, Shao-Hong Feng, Hao Zhang, Abul Kashem Fazlul Haque Bhuiyan, Muhammad Sajjad Khan, Gamamada Liyanage Lalanie Pradeepa Silva, Le Thi Thuy, Okeyo A. Mwai, Mohamed Nawaz Mohamed Ibrahim, Guojie Zhang, Kai-Xing Qu, Olivier Hanotte, Beth Shapiro, Mirte Bosse, Dong-Dong Wu, Jian-Lin Han, and Ya-Ping Zhang. 2021. Large-scale genomic analysis reveals the genetic cost of chicken domestication. BMC Biology 16;19(1):118.

16). Suyun Liang, Ming-Shan Wang (co-1st), Bo Zhang, Yulong Feng, Jing Tang, Ming Xie, Wei Huang, Qi Zhang, Dabing Zhang and Shuisheng Hou. 2021.NOD1 is associated with the susceptibility of Pekin duck flock to duck hepatitis A virus genotype 3. Frontiers in Immunology. 12:766740. doi: 10.3389/fimmu.2021.766740

17). Ming-Shan Wang, Mukesh Thakur, Yadvendradev Jhala, Sheng Wang, Yellapu Srinivas, Shan-Shan Dai, Zheng-Xi Liu, Hong-Man Cheng, Richard E. Green,Klaus-Peter Koepfli, Beth Shapiro. 2021. Genome sequencing of a gray wolf from peninsular India provides new insights into the evolution and hybridization of gray wolves. Genome Biology and Evolution, 14(2):evac012.

18). Ming-Shan Wang, Gemma G. R. Murray, Daniel Mann, Pamela Groves, Alisa O. Vershinina, Megan A. Supple, Joshua D. Kapp, Russell Corbett-Detig, Sarah E. Crump, Ian Stirling, Kristin L. Laidre, Michael Kunz, Love Dalén, Richard E. Green, Beth Shapiro; 2022. A polar bear paleogenome reveals extensive ancient gene flow from polar bears into brown bears, Nature Ecology & Evolution, 6(7):936-944.

  研究团队

助理研究员:司思,邹天天

助理实验师:张昶,刘正喜

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