Time: 15:30-17:00, Sep 2^nd (Monday) 

　　Venue: Room 315 SIBS Main Building, No. 320 Yueyang Road, Shanghai, China 

　　Speaker: Yi Xing, Ph.D. 

　　Francis West Lewis Chair 

　　Director, Center for Computational and Genomic Medicine 

　　The Children's Hospital of Philadelphia 

　　Professor of Pathology and Laboratory Medicine 

　　Perelman School of Medicine, University of Pennsylvania 

　　Host: Prof. Shuhua Xu 

　　 

　　Title: Alternative splicing variation across human tissues and individuals 

　　Abstract: Alternative splicing is a tightly regulated biological process by which the number of gene products for any given gene can be greatly expanded. Genomic variants in splicing regulatory sequences can disrupt splicing and cause disease. Recent developments in sequencing technologies and computational biology have allowed researchers to investigate alternative splicing at an unprecedented scale and resolution. Population-scale transcriptome studies have revealed many naturally occurring genetic variants that modulate alternative splicing and consequently influence phenotypic variability and disease susceptibility. In this talk, I will describe our efforts in characterizing alternative splicing variation across human tissues and individuals, and in mapping such variation to genotypes and phenotypes across human populations.  

  

Introduction of Speaker: 

Dr. Yi Xing is the Francis West Lewis Chair and Founding Director of the Center for Computational and Genomic Medicine at the Children’s Hospital of Philadelphia (CHOP), and Professor of Pathology and Laboratory Medicine at the University of Pennsylvania (Penn). Prior to his appointment at CHOP and Penn, Dr. Xing was a Professor of Microbiology, Immunology, and Molecular Genetics at UCLA, and served as Program Director of UCLA’s Bioinformatics Interdepartmental Ph.D. Program. Dr. Xing received his B.S. in Molecular and Cellular Biology and B.E. in Computer Science and Technology from the University of Science and Technology of China (2001). He completed his Ph.D. training in Bioinformatics with Dr. Christopher Lee at UCLA (2001-2006), and his postdoctoral training with Drs. Wing Hung Wong and Matthew Scott at the Stanford University (2006-2007). Dr. Xing has an extensive publication record in bioinformatics, genomics, and RNA biology. His work has provided fundamental insights into the function, regulation, and evolution of post-transcriptional RNA processing in mammals. His current research merges the fields of computational biology, biomedical data science, RNA genomics, human genetics, precision medicine, and immuno-oncology.