简历

郭永博，男，博士，副研究员。从事高原低氧适应关键表型的遗传学研究，相关研究结果发表在Current Biology、Genome Biology、Journal of Genetics and Genomics、iScience、eLife和Zoological Research等学术期刊，先后主持国家自然科学基金委青年科学基金项目（C类）、入选“兴滇英才支持计划”青年人才和项目支持。

学习和工作经历

2026-02 至 今, 中国科学院昆明动物研究所, 环境与精神健康学科组, 副研究员

2024-01 至 2026-01, 中国科学院昆明动物研究所, 环境与精神健康学科组, 助理研究员

2018-09 至 2023-12, 中国科学院大学, 遗传学, 博士

2014-09 至 2017-06, 甘肃农业大学, 动物遗传育种与繁殖, 硕士

2010-09 至 2014-06, 甘肃农业大学, 水产养殖学, 学士

围绕机体低氧响应与生物节律调控，利用细胞和动物模型解析低氧应答的生物学机制，并进一步探究低氧环境下生物节律紊乱及其对机体健康与保护性响应的影响机制。

1. 2023-2024学年获中国科学院大学博士国家奖学金；

1、Yongbo Guo; Wangshan Zheng; Tian Yue; Baimakangzhuo; Xuebin Qi; Kai Liu; Liya Li; Yaoxi

He; Bing Su; GCH1 contributes to high-altitude adaptation in Tibetans by regulating blood nitric

oxide, Journal of Genetics and Genomics, 2026, 53(1): 97-109. ( 本人标注: 共同第一作者 )

2、Yongbo Guo; Yaoxi He; Chaoying Cui; Ouzhuluobu; Baimakangzhuo; Duojizhuoma; Dejiquzong; Bianba; Gonggalanzi; Yongyue Pan; Qula; Min Kang; Cirenyangji; Baimayangji; Wei Guo; Yangla; Hui Zhang; Xiaoming Zhang; Wangshan Zheng; Shuhua Xu; Hua Chen; Shengguo Zhao; Yuan Cai; Shiming Liu; Tianyi Wu; Xuebin Qi; Bing Su; GCH1 plays a role in the high-altitude adaptation of Tibetans, Zoological Research, 2017, 38(3): 155-162. ( 本人标注: 共同第一作者 )

3、Yaoxi He; Yongbo Guo; Wangshan Zheng; Tian Yue; Hui Zhang; Bin Wang; Zhanying Feng;

Ouzhuluobu; Chaoying Cui; Kai Liu; Bin Zhou; Xuerui Zeng; Liya Li; Tianyun Wang; Yong Wang; Chao Zhang; Shuhua Xu; Xuebin Qi; Bing Su; Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude, Current Biology, 2023, 33(19): 4037-4051.e5. ( 本人标注: 共同第一作者 )

4、Tian Yue; Yongbo Guo; Xuebin Qi; Wangshan Zheng; Hui Zhang; Bin Wang; Kai Liu; Bin Zhou; Xuerui Zeng; Ouzhuluobu; Yaoxi He; Bing Su; Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development, eLife, 2024, 12(无):RP89004. ( 本人标注: 共同第一作者 )

5、Wangshan Zheng; Yaoxi He; Yongbo Guo; Tian Yue; Hui Zhang; Jun Li; Bin Zhou; Xuerui Zeng; Liya Li; Bin Wang; Jingxin Cao; Li Chen; Chunxia Li; Hongyan Li; Chaoying Cui; Caijuan Bai; Baimakangzhuo; Xuebin Qi; Ouzhuluobu; Bing Su; Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans, Genome Biology, 2023, 24(1):73. ( 本人标注: 共同第一作者 )

6、Yaoxi He, Wangshan Zheng, Yongbo Guo, Tian Yue, Chaoying Cui, Ouzhuluobu, Hui Zhang, Kai Liu, Zhaohui Yang, Tianyi Wu, Jia Qu,  Zi-Bing Jin, Jian Yang, Fan Lu, Xuebin Qi*, Bing Su. 2023. Deep phenotyping of 11,880 highlanders reveals novel adaptive traits in native Tibetans. iScience 26(9), 107677. ( 本人标注: 共同第一作者 )

7、Zhaohui Yang, Caijuan Bai, Youwei Pu, Qinghong Kong, Yongbo Guo; Ouzhuluobu; Gengdeng; Xuyang Liu, Qi Zhao, Zhichao Qiu, Wangshan Zheng, Yaoxi He, Yihan Lin, Lian Deng, Chao Zhang, Shuhua Xu, Yi Peng, Kun Xiang, Xiaoming Zhang; Baimayangji; Cirenyangji; Chaoying Cui; Baimakangzhuo; Gonggalanzi; Bianba; Yongyue Pan, Jingxue Xin, Yong Wang, Shiming Liu, Liangbang Wang, Hengliang Guo, Zhenzhen Feng, Shaobo Wang, Hong Shi, Binghua Jiang, Tianyi Wu, Xuebin Qi, Bing Su, 2022. Genetic adaptation of skin pigmentation in highland Tibetans. Proc. Natl. Acad. Sci. U. S. A. 119(40), e2200421119. ( 本人标注: 共同第一作者 )

8、Yaoxi He, Jun Li, Tian Yue, Wangshan Zheng, Yongbo Guo, Hui Zhang, Li Chen, Chunxia Li, Hongyan Li, Chaoying Cui, Ouzhuluobu, Xuebin Qi, Bing Su, 2022. Seasonality and Sex-Biased Fluctuation of Birth Weight in Tibetan Populations. Phenomics 2(1), 64-71. ( 本人标注: 共同第一作者 )