| 论文题目: | Sex-biased Regulatory Changes in the Placenta of Native Highlanders Contribute to Adaptive Fetal Development |
| 作者: | Tian Yue,Yongbo Guo,Xuebin Qi,Wangshan Zheng,Hui Zhang,Bin Wang,Kai Liu,Bin Zhou,Xuerui Zeng,Ouzhuluobu,Yaoxi He,Bing Su |
| 联系作者: | sub@mail.kiz.ac.cn |
| 发表年度: | 2023 |
| DOI: | |
| 摘要: | Compared with lowlander migrants, native Tibetans have a higher reproductive success at high altitude though the underlying mechanism remains unclear. Here, we compared the transcriptome and histology of full-term placentas between native Tibetans and Han migrants. We found that the placental trophoblast shows the largest expression divergence between Tibetans and Han, and Tibetans show decreased immune response and endoplasmic reticulum stress. Remarkably, we detected a sex-biased expression divergence, where the male-infant placentas show a greater between-population difference than the female-infant placentas. The umbilical cord plays a key role in the sex-biased expression divergence, which is associated with the higher birth weight of the male newborns of Tibetans. We also identified adaptive histological changes in the male-infant placentas of Tibetans, including a larger umbilical cord vein area and wall thickness, and fewer syncytial knots. These findings provide valuable insights into the sex-biased adaptation of human populations, with significant implications for medical and genetic studies of human reproduction |
| 刊物名称: | eLife |
| 论文出处: | https://elifesciences.org/reviewed-preprints/89004v1#mainMenu |
| 影响因子: | 7.7(2022IF) |
