| 论文题目: | The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project |
| 作者: | Lingzhao Fang, Jinyan Teng, Qing Lin, Zhonghao Bai, Shuli Liu, Dailu Guan, Bingjie Li, Yahui Gao, Yali Hou, Mian Gong, Zhangyuan Pan, Ying Yu, Emily L Clark, Jacqueline Smith, Konrad Rawlik, Ruidong Xiang, Amanda J Chamberlain, Michael E Goddard, Mathew Littlejohn, Greger Larson, David E MacHugh, John F O'Grady, Peter Sørensen, Goutam Sahana, Mogens Sandø Lund, Zhihua Jiang, Xiangchun Pan, Wentao Gong, Haihan Zhang, Xi He, Yuebo Zhang, Ning Ga, Jun He, Guoqiang Yi, Yuwen Liu, Zhonglin Tang, Pengju Zhao, Yang Zhou, Liangliang Fu, Xiao Wang, Dan Hao, Lei Liu, Siqian Chen, Robert S Young, Xia Shen, Charley Xia, Hao Cheng, Li Ma, John B Cole, Ransom L Baldwin th, Cong-Jun Li, Curtis P Van Tassell, Benjamin D Rosen, Nayan Bhowmik, Joan Lunney, Wansheng Liu, Leluo Guan, Xin Zhao, Eveline M Ibeagha-Awemu, Yonglun Luo, Lin Lin, Oriol Canela-Xandri, Martijn F L Derks, Richard P M A Crooijmans, Marta Gòdia, Ole Madsen, Martien A M Groenen, James E Koltes, Christopher K Tuggle, Fiona M McCarthy, Dominique Rocha, Elisabetta Giuffra, Marcel Amills, Alex Clop, Maria Ballester, Gwenola Tosser-Klopp, Jing Li, Chao Fang, Ming Fang, Qishan Wang, Zhuocheng Hou, Qin Wang, Fuping Zhao, Lin Jiang, Guiping Zhao, Zhengkui Zhou, Rong Zhou, Hehe Liu, Juan Deng, Long Jin, Mingzhou Li, Delin Mo, Xiaohong Liu, Yaosheng Chen, Xiaolong Yuan, Jiaqi Li, Shuhong Zhao, Yi Zhang, Xiangdong Ding, Dongxiao Sun, Hui-Zeng Sun, Cong Li, Yu Wang, Yu Jiang, Dongdong Wu, Wenwen Wang, Xinzhong Fan, Qin Zhang, Kui Li, Hao Zhang, Ning Yang, Xiaoxiang Hu, Wen Huang, Jiuzhou Song, Yang Wu, Jian Yang, Weiwei Wu, Claudia Kasper, Xinfeng Liu, Xiaofei Yu, Leilei Cui, Xiang Zhou, Seyoung Kim, Wei Li, Hae Kyung Im, Edward S Buckler, Bing Ren, Michael C Schatz, Jingyi Jessica Li, Abraham A Palmer, Laurent Frantz, Huaijun Zhou, Zhe Zhang, George E Liu; FarmGTEx Consortium |
| 联系作者: | lingzhao.fang@qgg.au.dk; zhezhang@scau.edu.cn; hzhou@ucdavis.edu; george.liu@usda.gov; lijy03@g.ucla.edu; aap@ucsd.edu; laurent.frantz@lmu.de |
| 发表年度: | 2025 |
| DOI: | DOI: 10.1038/s41588-025-02121-5 |
| 摘要: | Genetic mutation and drift, coupled with natural and human-mediated selection and migration, have produced a wide variety of genotypes and phenotypes in farmed animals. We here introduce the Farm Animal Genotype-Tissue Expression (FarmGTEx) Project, which aims to elucidate the genetic determinants of gene expression across 16 terrestrial and aquatic domestic species under diverse biological and environmental contexts. For each species, we aim to collect multiomics data, particularly genomics and transcriptomics, from 50 tissues of 1,000 healthy adults and 200 additional animals representing a specific context. This Perspective provides an overview of the priorities of FarmGTEx and advocates for coordinated strategies of data analysis and resource-sharing initiatives. FarmGTEx aims to serve as a platform for investigating context-specific regulatory effects, which will deepen our understanding of molecular mechanisms underlying complex phenotypes. The knowledge and insights provided by FarmGTEx will contribute to improving sustainable agriculture-based food systems, comparative biology and eventual human biomedicine. |
| 刊物名称: | Nature Genetics |
| 论文出处: | https://www.nature.com/articles/s41588-025-02121-5 |
| 影响因子: | 29(2024IF) |
