| 论文题目: | Shrew's Venom Quickly Causes Circulation Disorder, Analgesia and Hypokinesia |
| 作者: | Liao, ZY; Tang, XP; Chen, WL; Jiang, XL; Chen, ZZ; He, K; Li, Q; Duan, ZL; He, XQ; Kamau, PM; Lv, LB; Zhang, ZY; Rong, MQ; Lv, QM; Lai, R |
| 联系作者: | rlai@mail.kiz.ac.cn |
| 发表年度: | 2022 |
| DOI: | doi: 10.1007/s00018-021-04116-x |
| 摘要: | Multiple representatives of eulipotyphlan mammals such as shrews have oral venom systems. Venom facilitates shrews to hunt and/or hoard preys. However, little is known about their venom composition, and especially the mechanism to hoard prey in comatose states for meeting their extremely high metabolic rates. A toxin (BQTX) was identified from venomous submaxillary glands of the shrew Blarinella quadraticauda. BQTX is specifically distributed and highly concentrated (similar to 1% total protein) in the organs. BQTX shares structural and functional similarities to toxins from snakes, wasps and snails, suggesting an evolutional relevancy of venoms from mammalians and non-mammalians. By potentiating thrombin and factor-XIIa and inhibiting plasmin, BQTX induces acute hypertension, blood coagulation and hypokinesia. It also shows strong analgesic function by inhibiting elastase. Notably, the toxin keeps high plasma stability with a 16-h half-life in-vivo, which likely extends intoxication to paralyze or immobilize prey hoarded fresh for later consumption and maximize foraging profit |
| 刊物名称: | Cellular and Molecular Life Sciences |
| 论文出处: | https://link.springer.com/article/10.1007/s00018-021-04116-x |
| 影响因子: | 9.261(2020IF) |
