| 论文题目: | A Single-nucleus Transcriptomic Atlas of the Dog Hippocampus Reveals the Potential Relationship between Specific Cell Types and Domestication |
| 作者: | Qi-Jun Zhou, Xingyan Liu, Longlong Zhang, Rong Wang, Tingting Yin, Xiaolu Li, Guimei Li, Yuqi He, Zhaoli Ding, Pengcheng Ma, Shi-Zhi Wang, Bingyu Mao, Shihua Zhang, Guo-Dong Wang |
| 联系作者: | wanggd@mail.kiz.ac.cn |
| 发表年度: | 2022 |
| DOI: | |
| 摘要: | The process of domestication has to dramatic differences in behavioral traits between domestic dogs and compared to gray wolves. Whole-genome research found that a class of putative positively selected genes were related to various aspects of learning and memory, such as long-term potentiation and long-term depression. In this study, we constructed a single-nucleus transcriptomic atlas of the dog hippocampus to illustrate its cell types, cell lineage, and molecular features. Using the transcriptomes of 105 057 nuclei from the hippocampus of a Beagle dog, we identified 26 cell clusters and a putative trajectory of oligodendrocyte development. Comparative analysis revealed a significant convergence between dog differentially expressed genes (DEGs) and putative positively selected genes (PSGs). Forty putative PSGs were DEGs in glutamatergic neurons, especially in Cluster 14, which is related to the regulation of nervous system development. In summary, this study provides a blueprint to understand the cellular mechanism of dog domestication |
| 刊物名称: | National Science Review |
| 论文出处: | https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwac147/6649222 |
| 影响因子: | 23.178(2021IF) |
