| 论文题目: | Scrutiny of Genome-wide Somatic Mutation Profiles in Centenarians Identifies the Key Genomic Regions for Human Longevity |
| 作者: | Hao-Tian Wang, Long Zhao, Li-Qin Yang, Ming-Xia Ge, Xing-Li Yang, Zong-Liang Gao, Yu-Peng Cun, Fu-Hui Xiao, Qing-Peng Kong |
| 联系作者: | kongqp@mail.kiz.ac.cn |
| 发表年度: | 2023 |
| DOI: | doi: 10.1111/acel.13916 |
| 摘要: | Somatic mutations accumulate with age and are associated closely with human health, their characterization in longevity cohorts remains largely unknown. Here, by analyzing whole genome somatic mutation profiles in 73 centenarians and 51 younger controls in China, we found that centenarian genomes are characterized by a markedly skewed distribution of somatic mutations, with many genomic regions being specifically conserved but displaying a high function potential. This, together with the observed more efficient DNA repair ability in the long-lived individuals, supports the existence of key genomic regions for human survival during aging, with their integrity being of essential to human longevity |
| 刊物名称: | Aging Cell |
| 论文出处: | https://onlinelibrary.wiley.com/doi/10.1111/acel.13916 |
| 影响因子: | 7.8(2022IF) |
