| 论文题目: | Polygenic Adaptation Leads to a Higher Reproductive Fitness of Native Tibetans at High Altitude |
| 作者: | Yaoxi He, Yongbo Guo, Wangshan Zheng, Tian Yue, Hui Zhang, Bin Wang, Zhanying Feng, Ouzhuluobu, Chaoying Cui, Kai Liu, Bin Zhou, Xuerui Zeng, Liya Li, Tianyun Wang, Yong Wang, Chao Zhang, Shuhua Xu, Xuebin Qi, Bing Su |
| 联系作者: | sub@mail.kiz.ac.cn |
| 发表年度: | 2023 |
| DOI: | doi: 10.1016/j.cub.2023.08.021 |
| 摘要: | The adaptation of Tibetans to high-altitude environments has been studied extensively. However, the direct assessment of evolutionary adaptation, i.e., the reproductive fitness of Tibetans and its genetic basis, remains elusive. Here, we conduct systematic phenotyping and genome-wide association analysis of 2,252 mother-newborn pairs of indigenous Tibetans, covering 12 reproductive traits and 76 maternal physiological traits. Compared with the lowland immigrants living at high altitudes, indigenous Tibetans show better reproductive outcomes, reflected by their lower abortion rate, higher birth weight, and better fetal development. The results of genome-wide association analyses indicate a polygenic adaptation of reproduction in Tibetans, attributed to the genomic backgrounds of both the mothers and the newborns. Furthermore, the EPAS1-edited mice display higher reproductive fitness under chronic hypoxia, mirroring the situation in Tibetans. Collectively, these results shed new light on the phenotypic pattern and the genetic mechanism of human reproductive fitness in extreme environments |
| 刊物名称: | Current Biology |
| 论文出处: | https://www.sciencedirect.com/science/article/pii/S0960982223010643?via%3Dihub |
| 影响因子: | 9.2(2022IF) |
