(#共同一作，*共同通讯)
2024
[1] Zhang GQ, Samarawickrama PN, Gui L, Ma Y, Cao M, Zhu H, Li W, Yang HL, Li KC, Yang Y, Zhu EF, Li W*, He HY*. Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach. Aging and disease. 2024; doi: 10.14336/AD.2024.0065.
[2] Chen CJ#, Pan YZ#, Yang XY, Li HQ, Cai XH, He SY, Wang Q, Yang YW, Zheng RZ, Li HW, Yuan SJ, Dong X, Samarawickrama PN, Zi MT, He HY*, Zhang X*. Liver-targeting chimeras as a potential modality for the treatment of liver diseases. Journal of controlled release. 2024.
[3] Zhang YH#, Liu JH#, Zheng RZ, Hou KL, Zhang YD, Jia TX, Lu XY, Samarawickrama PN, Jia ST*, He HY*, Liu J*. Curcumin analogue EF24 prevents alveolar epithelial cell senescence to ameliorate idiopathic pulmonary fibrosis via activation of PTEN. Phytomedicine. 2024 (Accepted).
[4] Zeng M#, Zhou T#, Li ZY#, Li GM, Zhang SR, Wang L, Huang QG, Li JD, Samarawickrama PN, He HY*, Wang GD*. Transcriptomic and intervention evidence reveals domestic dogs as a promising model for anti-inflammatory investigation. Aging Cell. 2024; 23(5):e14127.
[5] Zhang X#, He HY#, Liu XG, Zhang X, Shi PZ, Wang YY, Zhou DH, Zheng GR*. Design and optimization of piperlongumine analogs as potent senolytics. Bioorg Med Chem Lett. 2024; 98:129593.
2023
[1] Hu L#, Dong CJ#, Wang Z, He SY, Yang YW, Zi MT, Li HQ, Zhang YH, Chen CJ, Zheng RZ, Jia ST, Liu J, Zhang X*, He YH*. A rationally designed fluorescence probe achieves highly specific and long-term detection of senescence in vitro and in vivo. Aging Cell. 2023; 22(8):e13896.
[2] Huang YQ#, Ge MX#, Li YH#, Li JL, Yu Q, Xiao FH, Ao HS, Yang LQ, Li J*, He YH*, Kong QP*. Longevity-associated transcription factor ATF7 promotes healthspan by suppressing cellular senescence and systematic inflammation. Aging and disease. 2023; 14(4):1374-1389.
[3] Xiao FH#, Wang HT#, Chen XQ, Ge MX, Yan DJ, Yang XL, Lin R, Guo RH, Zhang W, Tang NLS, He YH, Zhou JM, Cai WW*, Kong QP*. Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging. National Science Review. 2023; 10(6): nwad067.
2022
[1] Guo LY#, Chen YJ#, Li HQ, Yin FQ, Ge MX, Hu L, Zi MT, Qin ZH, He YH*. Telomere length is maternally inherited and associated with lipid metabolism in Chinese population. Aging-US. 2022; 14(1):354-367.
[2] Hu L#, Li HQ#, Zi MT, Li W, Liu J, Yang Y, Zhou DH, Kong QP, Zhang YX*, He YH*. Why senescent cells (SnCs) are resistant to apoptosis: An insight for senolytic development. Frontiers in Cell and Developmental Biology. 2022; 10:822816.
[3] Xiao FH#, Yu Q#, Deng ZL#, Yang K, Ye YS, Ge MX, Yan DJ, Wang HT, Chen XQ, Yang LQ, Yang BY, Lin R, Zhang W, Yang XL, Dong L, He YH, Zhou JM, Cai WW*, Li Ji*, Kong QP*. ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity. Science Advances. 2022; 8(17):eabf2017.
2021
[1] Ge MX, Hu L, Ao HS, Zi MT, Kong QP*, He YH*. Senolytic targets and new strategies for clearing senescent cells. Mechanisms of Ageing and Development. 2021; 195:111468.
[2] He YH*,#, Li W*, Zhang JL, Yang Y, Qian YW, Zhou DH. The curcumin analog EF24 is highly active against chemotherapy-resistant melanoma cells. Current Cancer Drug Targets. 2021; 21(7):608-618.
2020
[1] He YH#, Zhang X(uan)#, Chang JH#, Kim H#, Zhang PY, Wang YY, Khan Sajid, Liu XG, Zhang X(in), Lv DW, Li W, Thummuri Dinesh, Yuan YX, Elisseeff Jennifer, Campisi Judith, Almeida Maria, Song L, Zheng GR*, Zhou DH*. Using Proteolysis-Targeting Chimera Technology to Reduce Navitoclax Platelet Toxicity and Improve Its Senolytic Activity. Nature Communications. 2020; 11(1):1996.
[2] He YH, Koch R, Budamagunta V, Zhang PY, Zhang X(uan), Khan S, Thummuri D, Ortiz Y. T, Zhang X(in), Lv DW, Wiegand J. S, Li W, Palmer A. C, Zheng GR, Weinstock D. M*, Zhou DH*. DT2216–a Bcl-xL specific degrader is highly active against Bcl-xL-dependent T-cell lymphomas. Journal of Hematology & Oncology. 2020; 13(1):95.
[3] He YH, Wen Li, Lv DW, Zhang Xin, Zhang X, Campisi Judith, Zheng GR, Zhou DH*. Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. Aging Cell. 2020; 19(3):e13117.
[4] He YH#, Khan S#, Huo ZG, Lv DW, Zhang X, Liu XG, Yuan YX, Hromas R, Xu MJ, Zheng GR, Zhou DH*. Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies. Journal of Hematology & Oncology. 2020; 13(1):103.
[5] He YH, Zheng GR, Zhou DH. Senolytic Drug Development. In: Senolytics in Disease, Ageing and Longevity. Healthy Ageing and Longevity. Springer, Cham. 2020; 11. doi: 10.1007/978-3-030-44903-2_1 (Book chapter)
[6] Khan S#, He YH#, Zhang X, Yuan YX, Pu SY, Kong QP, Zheng GR, Zhou DH*. PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics. Oncogene. 2020; 39(26):4909-4924.
[7] Zhang X#, He YH#, Zhang PY#, Budamagunta V, Lv DW, Thummuri D, Yang Y, Pei J, Yuan YX, Zhou DH*, Zheng GR*. Discovery of IAP-Recruiting BCL-XL PROTACs as Potent Degraders across Multiple Cancer Cell Lines. European Journal of Medicinal Chemistry. 2020; 199:112397.
[8] Kim HN#, Xiong JH#, MacLeod RS, Iyer S, Fujiwara Y, Cawley KM, Han L, He YH, Thostenson JD, Ferreira E, Jilka RL, Zhou DH, Almeida M*, O'Brien CA*. Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence. JCI Insight. 2020; 5(19):e138815.
2019
[1] Khan Sajid#, Zhang X#, Lv DW#, Zhang Q, He YH, Zhang PY, Yuan YX, Liu XG, Thummuri Dinesh, Wiegand Janet, Ferrando Adolfo, Hromas Robert, Konopleva Maria, Zheng GR*, Zhou DH*. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nature Medicine. 2019; 25(12):1938-1947.
[2] He YH, Thummuri D, Zheng GR, Okunieff P, Citrin DE, Vujaskovic Z, Zhou DH*. Cellular Senescence and Radiation-induced Pulmonary Fibrosis. Translational Research. 2019; 209:14-21.
[3] Yu Q, Pu SY, Wu H, Chen XQ, Jiang JJ, Gu KS, He YH*, Kong QP*. TICRR Contributes to Tumorigenesis through Accelerating DNA Replication in Cancers. Front Oncol. 2019; 9:516.
[4] Li W#, Qin L#, Feng RN, Hu GR, Sun H, He YH*, RP Zhang*. Emerging senolytic agents derived from natural products. Mechanisms of Ageing and Development. 2019; 181:1-6.
2018
[1] Xiao FH#, Chen XQ#, Yu Q#, Ye YS#, Liu YW, Yan DJ, Yang LQ, Chen GJ, Lin R, Yang LP, Liao XP, Zhang W, Zhang W, Wang XF, Zhou JM*, Cai WW*, He YH*, Kong QP*. Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Research. 2018; 28(11):1601-1610.
[2] He YH*, Li Wen, Hu GR, Kong QP. Bioactivities of EF24, a novel curcumin analog: A review. Frontiers in Oncology. Front Oncol. 2018; 11(8):614.
[3] Yuan LF, Zhai LH, Qian LL, Huang D, Ding Y, Xiang HD, Dr. Liu XJ, Thompson W, Liu J, He YH, Chen XQ, Hu J, Kong QP, Tan MJ, Wang XF*. Switching off IMMP2L Signaling Drives Senescence via Simultaneous Metabolic Alteration and Blockage of Cell Death. Cell Research. 2018; 28(6):625-643.
[4] Zhang X, Zhang SP, Liu XG, Wang YY, Chang JH, Zhang X, Mackintosh S, Tackett A, He YH, Lv DW, Laberge RM, Campisi J, Wang JR, Zheng GR, Zhou DH*. Oxidation resistance 1 is a novel senolytic target. Aging Cell. 2018; 17(4):e12780.
2017
[1] Li QG#, He YH#, Wu H#, Yang CP, Pu SY, Fan SQ, Jiang LP, Shen QS, Wang XX, Chen XQ, Yu Q, Li Y, Sun C, Wang XT, Zhou JM, Li HP, Chen YB*, Kong QP*. A normalization-free and nonparametric method sharpens pan-cancer expression analysis. Theranostics. 2017; 7(11):2888-2899.
2016
[1] He YH#, Chen XQ#, Yan DJ, Xiao FH, Lin R, Liao XP, Liu YW, Pu SY, Yu Q, Sun HP, Jiang JJ, Cai WW*, Kong QP*. Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring. Neurobiology of Aging. 2016; 47:218.e11-218.e18.
[2] He YH#, Lu X#, Tian JY, DJ Yan, Li YC, Lin R, Perry B, Chen XQ, Yu Q, Cai WW*, Kong QP*. Mitochondrial DNA contributes equally to female and male longevity in Chinese centenarians. Experimental Gerontology. 2016; 83:94-96.
[3] Xiao FH, Kong QP, Perry B, He YH*. Progress on the role of DNA methylation in aging and longevity. Briefings in Functional Genomics. 2016; 15(6):454-459.
[4] Han LY, Liu YF, Duan SW, Perry B, Li W*, He YH*. DNA methylation and hypertension: emerging evidence and challenges. Briefings in Functional Genomics. 2016; 15(6):460-469.
[5] Jiang JJ, Cheng LH, Wu H, He YH*, Kong QP*. Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance. Epigenetics & Chromatin. 2016; 9:51.
2015
[1]He YH, Chen XQ, Yan DJ, Xiao FH, Liu YW, Lin R, Liao XP, Cai WW*, Kong QP*. Thyroid function decreases with age and may contribute to longevity in Chinese centenarians’ families. J Am Geriatr Soc. 2015; 63(7):1474-1476.
2014
[1]He YH, Lu X, Wu H, Cai WW*, Yang LQ, Sun HP, Kong QP*. MtDNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenarians. Neurobiology of Aging. 2014;35(7):1779.e1-1779.e14.
[2]He YH, Zhang YX, Yang LQ, Liao XP, Cai WW*, Kong QP*.Assessment of the health status of centenarians in the South of China: A cross-sectional study.J Am Geriatr Soc. 2014;62(7):1402-1404.
[3]He YH, Lu X, Yang LQ, Xu LY, Kong QP*. Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians. Aging-US. 2014; 6(11):944-56.
2013
[1] He YH, Li Y, Zhang SC, Perry B, Zhao TT, Wang YW*, Sun CH*. Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes. Biochemical and Biophysical Research Communications. 2013; 436:169-174.
[2] He YH, Perry B, Bi MX, Sun H, Zhao TT, Li Y*, Sun CH*. Allosteric regulation of the calcium-sensing receptor in obese individuals. International Journal of Molecular Medicine. 2013; 32:511-518.
[3] He YH, Li Y, Zhao TT, Wang YW*, Sun CH*. Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway. PLoS One. 2013; 8: 8(7):e70135.
2012
[1] He YH, Li ST, Wang YY, Wang G, He Y, Liao XL, Sun CH*, Li Y*. Postweaning low-calcium diet promotes later-life obesity induced by a high-fat diet. Journal of Nutritional Biochemistry. 2012; 23:1238-1244.
2011
[1] He YH, Song Y, Liao XL, Wang L, Li G, Alima, Li Y*, Sun CH*. The calcium-sensing receptor affects fat accumulation via effects on antilipolytic pathways in adipose tissue of rats fed low-calcium diets. Journal of Nutrition. 2011; 141(11):1938-46.
[2] He YH, Li ST, Wang YY, Wang G, He Y, Liao XL, Sun CH*, Li Y*. Postweaning low-calcium diet promotes later-life obesity induced by a high-fat diet. Journal of Nutritional Biochemistry. 2011; 23:1238-1244.
知识产权
[1] Zheng GR, Zhou DH, Zhang X, Khan S, He YH, Zhang PY. BCL-2 proteins degraders for cancer treatment. WO/2019/1441172019. 2019.
[2] Zhou DH, He YH, Zheng GR, Zhang X. USP7 inhibitor as potential senolytic agent and its applications. 052592-590174. 2018.
[3] Zhou DH, Zheng GR, He YH, Pi LY. Methods of treating diseases associated with senescent cell accumulation. WO2023064326A1. 2023.
[4] 何永捍，张翾，董婵娟，胡丽，王哲，何胜源. 一种靶向衰老细胞的近红外生物探针及其制备方法与用途. 202211569064.4. 2023.
[5] 何永捍，刘静，张阳焕，刘嘉华. 姜黄素类似物EF24 在制备治疗特发性肺纤维化药物中的用途. 202311445151.3
