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张国捷   研究员
生物多样性基因组研究学科组
职  务:
学  历: 理学博士
电  话: +86 871 68125417
传  真:
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通讯地址: 云南省昆明市盘龙区茨坝镇青松路21号    650203
其他主页: http://zhanggjlab.cn/en/pages/our_lab.html
CASKIZ-IR(机构知识库)个人主页
  简  历

博士,研究员。现任浙江大学求是讲席教授,兼任中国科学院昆明动物研究所特聘客座研究员。曾任丹麦哥本哈根大学生物系终身教授,中国国家基因库副主任。2004年毕业于厦门大学,2010年在中国科学院昆明动物研究所获得博士学位。2012年受欧盟玛丽居里青年基金资助赴哥本哈根大学担任助理教授,2015年成为哥本哈根大学终身序列助理教授,并于2017年3月获得终身副教授职位,同年7月被授予终身教授职位。2020年,在哥本哈根大学成立生物多样性基因组研究中心。2022年全职加入浙江大学后,成立生命演化研究中心。2023年获科学探索奖。2024年入选丹麦皇家文理科学院院士。2024年获“谈家桢生命科学创新奖”。张国捷教授在国际上较早提出并开展生物多样性基因组研究,课题研究主要围绕物种起源和适应机制,动物宏观水平大尺度演化过程及内在分子动力,复杂生物学性状的演化和发育机制。张国捷课题组综合比较基因组学、功能基因组学及比较形态学研究,厘清了多个代表性物种类群的起源及演化之谜,阐述了演化历史上辐射性物种大爆发过程中的基本规律,并揭示调控多种生物复杂性状的遗传机制,丰富了我们对物种形成、自然选择学说、和物种适应性遗传创新的理解,并为人类组织器官和功能的溯源及发育调控机制提供了演化视角下的新见解,相关研究成果于2019、2021、2023年入选“中国十大生命科学研究进展”。此外研究团队结合计算生物学和大数据信息处理,开发了一系列基因组学和演化基因组学的新方法,为未来健康大数据分析和多学科交叉研究奠定了基础。研究团队在国际顶级期刊发表270多篇研究论文,以第一或通讯作者在NatureScienceCell主刊发表研究论文20篇。多篇文章被选为封面文章,多个研究成果受到CNN、BBC、纽约时报、华盛顿邮报、国家地理等主流媒体广泛报道。论文总引用率超4.3万次,h-index 90。2018起多次入选全球高被引学者。张国捷及其合作团队的多篇成果曾三次在Science上以专刊(special issue)形式发表。张国捷教授组织和领导了多项国际基因组学协作计划,包括万种鸟类基因组研究计划(B10K),灵长类基因组计划(PGP),脊椎动物基因组研究联盟(VGP),及地球生命基因组计划(EBP)等,极大地推动了生物多样性基因组研究领域的发展。曾任首届亚洲演化生物学会议主席,先后担任美国、丹麦、中国、瑞士、瑞典、法国、英国、以色列、加拿大等十多个国家基金委员会的评委,常年受邀为NatureScienceCell等高水平杂志开展审稿工作。


工作经历:

2022.02-至今       浙江大学求是讲席教授

2017.09-2022.01    哥本哈根大学生物系终身正教授(Full Professor)

2017.03-2017.08    哥本哈根大学生物系终身副教授(Associate Professor)

2015.01-2017.02    大学生物系终身序列助理教授(Tenure-track Assis tant professor)

2015.01-至今       中国科学院昆明动物研究所特聘客座研究员

2012.08-2014.12    哥本哈根大学助理教授(Assistant Professor)

2010.06-2012.05    深圳华大生命科学研究院研究员


相关链接:

1.课题组主页:http://www.zhanggjlab.org/

2.演化中心主页:https://evolution.zju.edu.cn/

3.CRGD主页:https://genome.zju.edu.cn/

4.B10k 主页:https://b10k.com/

5.Global Ant Genomics Alliance: http://ant.genomics.dk/


  研究方向

地球生命的物种组成、形态、及功能多样性形成的遗传机制是达尔文留给后人的未解之谜,是生命科学研究中最基础的学科之一。生物多样性基因组学是新近发展起来的新兴综合性学科,旨在利用比较基因组学、演化生物学、群体遗传学、发育生物学、生态学等多个学科的理论和技术交叉,系统回答生物形态功能的分子遗传基础、物种协同演化分子机制,以及生物演化与环境互作机制等重要基础问题。张国捷教授是国际上首批开展生物多样性基因组学研究的学者之一,也是这一领域最为活跃学者之一,并在多个方向取得了突破性研究成果:

1)建立大尺度比较基因组学研究体系,在国际上引领重构生命之树的研究;

2)通过比较基因组学解释物种的环境适应机制,丰富达尔文自然选择理论;

3)基于多学科交叉,创建发育生物学新范式,推动非模式生物特异性状发育和演化的分子机理;

4)建立研究社会行为演化及分子调控机制的新型动物模型,揭示基因调控和表观遗传调控对社会行为的影响。

目前在昆明动物研究所的团队主要以蚂蚁为模型,研究基因调控和表观遗传对社会行为的影响,从而解释社会行为的演化及其分子机理。为研究这一命题,张国捷教授与团队成员在基因组层面、表观调控层面以及神经生物学层面对蚂蚁社会等级及行为差异展开系统研究。阐明了:

1)社会性昆虫的社会行为和社会组织基因组演化机制(Science 2010 Science 2015);

2)蚂蚁行为和形态等级分化的遗传和神经生物学基础(Nature Communications 2014);

3)蚂蚁等级分化的表观遗传基础(Current Biology 2012);

4)蚂蚁与其他物种的共生及共同演化机制(Genome Research 2011 Nature Communications 2016)

5)个体发育过程中的发育限制现象推动蚁后-工蚁之间的分工 Nature Ecology and Evolution 2022a);

6)蚂蚁等级特异大脑特化现象是个体之间大脑功能分化的原因 Nature Ecology and Evolution 2018 Nature Ecology and Evolution 2022b);

7保守的分子细胞机制调控蚂蚁生殖表型可塑性 (Science Advance 2020;PLOS Bio 2024);

8)蚂蚁个体发育分化的内激素核心作用机制 (PNAS 2024)。

目前在开展的研究包括:

1)全球蚂蚁基因组联盟计划(The Global Ant Genomics Alliance, GAGA

全球蚂蚁基因组联盟计划(http://antgenomics.dk/)将构建全球蚁科属级别代表物种的基因组图谱,提供最全面的蚂蚁基因组多样性数据。通过对这些基因组数据的比较分析,我们将可以理解蚂蚁演化的全球性趋势,并找到当今蚂蚁物种的多样性及其令人惊叹的适应性背后的遗传基础。根据我们之前完成的国际鸟类基因组演化项目的经验(Zhang et al. 2014),我们预期在系统发育框架下从全球范围内选取约200个有代表性行为生态特征的蚂蚁物种进行基因组分析,将会极大促进蚂蚁(乃至其他物种)生物学的研究,同时为未来数十年学术界回答不同的科学问题提供了大量的基础数据。

2)蚂蚁个体等级发育分化的调控机制

蚂蚁的等级分化是一个不可逆的过程,雌性在发育的过程中逐渐分化出了形态、生理和行为均不同的等级:蚁后专职负责繁衍后代,工蚁负责生殖外的其他工作。这一生殖分化与社会分工的发育过程类似于后生动物中个体生殖细胞系和体细胞系的分化过程。然而,与动物发育的巨大进展相比,我们对个体发育中等级分化的分子机制的理解是极其有限的。蚁后和工蚁等级分化的起点是什么时候?在具有相同遗传信息的状态下,蚁后和工蚁的分化是如何调控形成的?这些问题都是我们希望能去解答的。

本课题组主要以法老蚁(Monomorium pharaonis)作为研究模型,该物种工蚁的卵巢完全退化,彻底丧失生殖能力。而且,工蚁和蚁后早在二龄幼虫期开始已经展现出了外部形态上的差异。这些特征使它成为研究蚂蚁个体等级分化的遗传机理的理想模式物种。利用分子遗传学等方法来确定其等级分化的起点,并通过基因功能验证、表观遗传、激素处理等手段来确定等级分化的调控机制。

3)蚂蚁生殖分化的表型可塑性调控机制

动物社会组织的出现是生命演化历程中的重大转折性事件。除了蚁后和工蚁展现出来的等级分化外,在个体发育层面,雌性处女生殖蚁gyne完成交配转变为成熟蚁后queen过程中其生理、行为及生殖力均会发生剧烈变化。并且,交配后的queen打破了大多数动物中生殖会降低自身生存力的规律,她在活跃生殖的同时,寿命也得到了显著增长。

为了揭示蚂蚁生殖分化过程中,影响其生理、行为及大脑可塑性的基因调控事件。本课题组通过转录组分析、单细胞测序和原位杂交来追踪法老蚁蚁后建立过程中大脑基因表达的动态变化,并通过基因分子功能验证实验来解析相关神经激素的功能,从而了解蚁后建立过程中决定其生理与行为变化的神经激素调控机制,从个体发育角度挖掘超个体组织系统生殖分化的核心基因调控网络。进一步深入解析大脑-脂肪体-卵巢的器官互作机制,挖掘蚁后在生殖分化过程中的生理、行为及寿命协同变化的内在原因。

4)社会性昆虫衰老机制

人为什么会衰老?衰老是怎样发生的?如何延缓衰老?等问题,不但是长期以来人们普遍关切的问题,也是生命科学研究领域的重大问题。近年来随着高通量测序、多组学分析、基因编辑、功能实验技术等的飞速发展,人们逐渐将视角跳脱出传统模式动物,越来越多的非模式动物被引入到衰老研究中来。社会性昆虫相较于体型近似的独栖昆虫,其生殖等级的寿命会有上百倍的延长,一些物种的白蚁及蚂蚁蚁后其寿命可达到惊人的数十年;而且不同等级的寿命也表现出极大的可塑性,蚁后和工蚁都具有相同的二倍体基因组,然而其寿命却会有数倍到数十倍的差异。社会性昆虫的生殖品级在寿命得到极度延长的同时其生殖能力也极度提高,打破了独栖动物中普遍存在的生殖与寿命之间的代偿关系。传统的衰老演化理论难以解释这一现象,因此,研究社会性昆虫的衰老机制也有助于建立更为普适性的、更有解释力的新型理论框架。

为了揭示社会性昆虫衰老机制,我们综合比较转录组、单细胞测序、基因功能实验、药理学、衰老表征等多种研究手段,追踪不同组织、不同性别、不同等级、不同物种的衰老速率和分子细胞动态,比较衰老模式随社会组织系统演化的变化规律,最终挖掘蚁后寿命极度延长的内在原因,寻找抗衰老的新型作用机制。

5)蚂蚁工蚁多态性的发育演化机制

所有蚂蚁都是营社会性生活的,虽然其社会组织结构有简单复杂,但其社会性起源在演化历程中只发生过一次,所有蚂蚁的共同祖先是一种类似于胡蜂的独居昆虫。除了蚁科,蜜蜂科与胡蜂科的很多物种也是社会性的。然而相较于蜜蜂、胡蜂等其他膜翅目社会性昆虫,蚂蚁除了发生蚁后与工蚁的等级分化之外,在一些物种的工蚁内部还进一步产生了多样性的工蚁亚等级分化,如分化出大、中、小型工蚁、兵蚁和超级兵蚁等,呈现工蚁多态性(worker polymorphism)。工蚁多态性的产生使蚁群中的劳动分工得以进一步细化,社会通讯复杂程度加深,彼此紧密协作,使得蚁群作为一个“超个体”而具有更高的适合度,演化形成无脊椎动物中最为复杂的社会组织系统。

我们综合比较基因组学、转录组测序、单细胞分析和基因功能验证的研究手段来探究工蚁多态性的在分子及细胞水平上的演化模式,解析调控工蚁和兵蚁个体发育的基因调控网络和调控工蚁和兵蚁社会分工的神经作用机制,追踪多型工蚁大脑结构功能与基因调控网络的演化模式,最终揭示蚂蚁工蚁多型性产生及社会组织结构复杂化的驱动力和内在原因。


  承担科研项目

主持经费:

在过去11年中,共主持项目经费近2.5亿元,主要项目如下:

2024.01-2028.12    国自然基础科学中心(浙江大学参与,740万)

2023.07-2028.07    新基石科学基金会“科学探索奖”(300万元)

2020.01-2025.12    Villum Investigator Grant 40 million 丹麦克朗(4200万元)

2019.01-2023.12    Independent Research Fund Denmark 6million DKK (620万元)

2018.07-2023.06    中国科学院战略性先导科技专项(B类)(451.35万元)

2021.01-2022.12    中国科学院国际大科学计划培育专项(270万元)

2018.08-2021.12    “海洋环境安全保障”国家重点研发计划(228万元)

2015.01-2020.12    Lundbeck Fellowship € 1.3 million (1100万元)

2017.01-2020.12    Carlsberg Distinguished Associate Professorship Grant € 0.55 million (450万元) 

2015.01-2018.12    中国科学研究院重大突破项目(635万元)2017.07-2018.06      中国科学院B类先导科技专项培育项目(65万元)

2014.01-2017.12    Startup package at University of Copenhagen € 0.42 million (300万元)

2012.01-2014.12    Marie Curie Fellowship € 0.25 million (185万元)


  专家类别
研究员
  社会任职

重大国际研究计划任职:

2018年-至今 灵长类基因组计划研究联盟(The Primate Genome Project)发起人之一。其他成员有中国科学院昆明动物研究所吴东东研究员团队,西北大学生命科学学院齐晓光教授团队,云南大学生命科学学院于黎研究员团队,西班牙庞培法布拉大学联合演化生物学研究所Tomàs Marquès-Bonet教授团队,Illumina人工智能实验室,美国贝勒医学院人类基因组测序中心Jeffrey Rogers教授团队,丹麦奥胡斯大学Mikkel H. Schierup团队以及德国莱布尼茨灵长类研究所Christian Roos教授团队。


2017年-至今 地球生命基因组计划(Earth BioGenome Project)发起者之一、委员会成员。其他委员会成员包括Scott V. Edwards (哈佛大学,美国国家科学院(NAS)院士),Harris Lewin (UC Davis, 美国NAS院士,沃尔夫奖), David Haussler (UCSC, 美国NAS院士,美国科学发展协会AAAS院士,人工智能促进协会AAAI院士), Aristides A.N. Patrinos (美国能源部DOE JGI创办人,AAAS院士),Pamela S. Soltis (佛罗里达大学,美国NAS院士),Katherine J Willis (牛津大学,挪威科学院院士),Richard Durbin(Sanger研究院,欧洲分子生物学组织EMBO院士)等15名教授。


2016年-至今 全球蚂蚁行为基因组演化研究计划发起者、主持人(Global Ant Genomics Alliance)。参与成员包括:Jacobus J. Boomsma(哥本哈根大学,丹麦皇家科学院院士),Laurent Keller (洛桑大学,EMBO院士)等14位来自世界各地著名大学教授。


2015年-至今 万种鸟类基因组联盟发起者、主持人(Bird 10K project)。成员包括包括:Carsten Rahbek (哥本哈根大学,丹麦皇家科学院院士), David Burt (Roslin Institute,英国皇家科学院院士),Joel Cracraft (美国自然历史博物馆,AAAS院士)等20名来自世界各地著名大学教授。


2011年-2014 鸟纲演化基因组研究计划发起者、主持人(Avian Phylogenomics Project)。项目成果已于2014年在Science上发表8篇研究论文。成员包括:Carsten Rahbek(哥本哈根大学,丹麦皇家科学院院士), David Burt(Roslin Institute,英国皇家科学院院士),Joel Cracraft (美国自然历史博物馆,AAAS院士),Hans Ellegren(Uppsala大学,瑞典皇家科学院院士,EMBO院士),David Haussler (UCSC,美国NAS院士,AAAS院士,AAAI院士),Scott V. Edwards(哈佛大学,美国NAS院士),Eske Willerslev(哥本哈根大学,丹麦皇家科学院院士,美国NAS院士),Oliver Ryder(圣地亚哥动物园,美国AAAS院士)等30多名各大学正教授。


2010年-至今 万种脊椎动物基因组联盟项目协调人(Genome 10K Consortium)。


2010年-至今 全球基因组标准委员会成员(Genomic Standards Consortium)。


2016年-至今 GigaScience杂志编委。


2013年-至今 Encyclopedia of Life Sciences编委。


2012年-至今 国际生命复活计划委员会成员(De-extinction Project)。


  获奖及荣誉

2024年    第十七届“谈家桢生命科学创新奖”

2024年    丹麦皇家文理科学院院士

2023年    第五届“科学探索奖”

2021年    深圳市国家级高层次专业领军人才

2021年    中国生命科学十大进展

2020年    科睿唯安全球高被引学者(跨学科领域)(Highly Cited Researcher)

2019年    中国科学院“海外评审专家”

2019年    云南省高层次人才 “千人计划”专项

2019年    中国生命科学十大进展

2019年    Villum Investigator

2019年    科睿唯安全球高被引学者(跨学科领域)(Highly Cited Researcher)

2018年    科睿唯安全球高被引学者(跨学科领域)(Highly Cited Researcher)

2017年    深圳市自然科技一等奖

2017年    Nature Index封面人物

2016年    嘉士伯杰出副教授奖(The Carlsberg Foundation’s Distinguished    Associ ate Professor Fellowships )(丹麦)

2016年    深圳市海外高层次B类人才

2015年    Lundbeck Fellowship (丹麦)

2015年    第四届南粤科技创新优秀学术论文二等奖

2014年    深圳市青年科技奖

2014年    北极熊基因组论文获评“Cell年度中国论文”

2014年    指导的学生刘石平获评中国青少年科技创新奖

2013年    李汝琪动物遗传学奖(中国每两年两名获奖者)

2012年    玛丽居里青年学者基金 (欧盟)

2011年    Sir Frederick McMaster visiting fellow(澳大利亚CSIRO)

2011年    中国科学院百篇优秀论文

2011年    第十届云南省优秀科技论文奖(特等奖)

2010年    深圳市国家级高层次专业人才


  代表论著

封面论著(Selected Covers):



发表文章:

1.    J Stiller, S Feng, A-A Chowdhury, I Rivas-González, DA Duchêne, Q Fang, Y Deng, A Kozlov, A Stamatakis, S Claramunt, JMT Nguyen, SYW Ho, BC Faircloth, J Haag, P Houde, J Cracraft, M Balaban, U Mai, G Chen, R Gao, C Zhou, Y Xie, Z Huang, Z Cao, Z Yan, HA Ogilvie, L Nakhleh, B Lindow, B Morel, J Fjeldså, PA Hosner, RR Da Fonseca, B Petersen, JA Tobias, T Székely, JD Kennedy, AH Reeve, A Liker, M Stervander, A Antunes, DT Tietze, M Bertelsen, F Lei, C Rahbek, GR Graves, MH Schierup, T Warnow, EL Braun, MTP Gilbert, ED Jarvis, S Mirarab and G Zhang. Complexity of avian evolution revealed by family-level genomes. Nature (2024)

2.    S Mirarab, I Rivas-González, S Feng, J Stiller, Q Fang, U Mai, G Hickey, G Chen, N Brajuka, O Fedrigo, G Formenti, JBW Wolf, K Howe, A Antunes, MH Schierup, B Paten, ED Jarvis, G Zhang and EL Braun. A region of suppressed recombination misleads neoavian phylogenomics. Proceedings of the National Academy of Sciences 121, e2319506121. (2024)

3.   Y Xie and G Zhang. Phylogenomic analyses unraveled the evolution of viral tolerance in bats. Cell Genomics 4, (2024)

4.   B Hu, X-L Zhuang, L Zhou, G Zhang, DN Cooper and D-D Wu. Deciphering the Role of Rapidly Evolving Conserved Elements in Primate Brain Development and Exploring Their Potential Involvement in Alzheimer's Disease. Molecular Biology and Evolution 41, msae001. (2024)

5.   LFK Kuderna, JC Ulirsch, S Rashid, M Ameen, L Sundaram, G Hickey, AJ Cox, H Gao, A Kumar, F Aguet, MJ Christmas, H Clawson, M Haeussler, MC Janiak, M Kuhlwilm, JD Orkin, T Bataillon, S Manu, A Valenzuela, J Bergman, M Rouselle, FE Silva, L Agueda, J Blanc, M Gut, D De Vries, I Goodhead, RA Harris, M Raveendran, A Jensen, IS Chuma, JE Horvath, C Hvilsom, D Juan, P Frandsen, JG Schraiber, FR De Melo, F Bertuol, H Byrne, I Sampaio, I Farias, J Valsecchi, M Messias, MNF Da Silva, M Trivedi, R Rossi, T Hrbek, N Andriaholinirina, CJ Rabarivola, A Zaramody, CJ Jolly, J Phillips-Conroy, G Wilkerson, C Abee, JH Simmons, E Fernandez-Duque, S Kanthaswamy, F Shiferaw, D Wu, L Zhou, Y Shao, G Zhang, JD Keyyu, S Knauf, MD Le, E Lizano, S Merker, A Navarro, T Nadler, CC Khor, J Lee, P Tan, WK Lim, AC Kitchener, D Zinner, I Gut, AD Melin, K Guschanski, MH Schierup, RMD Beck, I Karakikes, KC Wang, G Umapathy, C Roos, JP Boubli, A Siepel, A Kundaje, B Paten, K Lindblad-Toh, J Rogers, T Marques Bonet and KK-H Farh. Identification of constrained sequence elements across 239 primate genomes. Nature 625, 735-742. (2024)

6.   G Femerling, C Van Oosterhout, S Feng, RM Bristol, G Zhang, J Groombridge, MT P. Gilbert and HE Morales. Genetic Load and Adaptive Potential of a Recovered Avian Species that Narrowly Avoided Extinction. Molecular Biology and Evolution 40, (2023)

7.   C Yang, Y Zhou, Y Song, D Wu, Y Zeng, L Nie, P Liu, S Zhang, G Chen, J Xu, H Zhou, L Zhou, X Qian, C Liu, S Tan, C Zhou, W Dai, M Xu, Y Qi, X Wang, L Guo, G Fan, A Wang, Y Deng, Y Zhang, J Jin, Y He, C Guo, G Guo, Q Zhou, X Xu, H Yang, J Wang, S Xu, Y Mao, X Jin, J Ruan and G Zhang. The complete and fully-phased diploid genome of a male Han Chinese. Cell Research 33, 745-761. (2023)

8.   PA O'brien, S Tan, PR Frade, SJ Robbins, JP Engelberts, SC Bell, I Vanwonterghem, DJ Miller, NS Webster, G Zhang and DG Bourne. Validation of key sponge symbiont pathways using genome-centric metatranscriptomics. Environmental Microbiology 25, 3207-3224. (2023)

9.   F Sánchez-Barreiro, B De Cahsan, MV Westbury, X Sun, A Margaryan, C Fontsere, MW Bruford, I-RM Russo, DC Kalthoff, T Sicheritz-Pontén, B Petersen, L Dalén, G Zhang, T Marquès-Bonet, MTP Gilbert and Y Moodley. Historic Sampling of a Vanishing Beast: Population Structure and Diversity in the Black Rhinoceros. Molecular Biology and Evolution 40, msad180. (2023)

10.X Zhuang, J Zhang, Y Shao, Y Ye, C Chen, L Zhou, Z Wang, X Luo, B Su, Y Yao, D Cooper, B Hu, L Wang, X Qi, J Lin, G Zhang, W Wang, N Sheng and DD Wu. Integrative omics reveals rapidly evolving regulatory sequences driving primate brain evolution. Molecular Biology and Evolution msad173. (2023)

11.Smith, JM Alfieri, N Anthony, P Arensburger, GN Athrey, J Balacco, A Balic, P Bardou, P Barela, Y Bigot, H Blackmon, PM Borodin, R Carroll, MC Casono, M Charles, H Cheng, M Chiodi, L Cigan, LM Coghill, R Crooijmans, N Das, S Davey, A Davidian, F Degalez, JM Dekkers, M Derks, AB Diack, A Djikeng, Y Drechsler, A Dyomin, O Fedrigo, SR Fiddaman, G Formenti, LaF Frantz, JE Fulton, E Gaginskaya, S Galkina, RA Gallardo, J Geibel, AA Gheyas, CJP Godinez, A Goodell, JaM Graves, DK Griffin, B Haase, J-L Han, O Hanotte, LJ Henderson, Z-C Hou, K Howe, L Huynh, E Ilatsia, ED Jarvis, SM Johnson, J Kaufman, T Kelly, S Kemp, C Kern, JH Keroack, C Klopp, S Lagarrigue, SJ Lamont, M Lange, A Lanke, DM Larkin, G Larson, JKN Layos, O Lebrasseur, LP Malinovskaya, RJ Martin, ML Martin Cerezo, AS Mason, FM Mccarthy, MJ Mcgrew, J Mountcastle, CK Muhonja, W Muir, K Muret, TD Murphy, I Ng’ang’a, M Nishibori, RE O’connor, M Ogugo, R Okimoto, O Ouko, HR Patel, F Perini, MI Pigozzi, KC Potter, PD Price, C Reimer, ES Rice, N Rocos, TF Rogers, P Saelao, J Schauer, RD Schnabel, VA Schneider, H Simianer, A Smith, MP Stevens, K Stiers, CK Tiambo, M Tixier-Boichard, AA Torgasheva, A Tracey, CA Tregaskes, L Vervelde, Y Wang, WC Warren, PD Waters, D Webb, S Weigend, A Wolc, AE Wright, D Wright, Z Wu, M Yamagata, C Yang, Z-T Yin, MC Young, G Zhang, B Zhao and H Zhou. Fourth Report on Chicken Genes and Chromosomes 2022. Cytogenetic and Genome Research 162, 405-528. (2023)

12.Y Guo, Y Shao, X Bi, B Zhang, H Wu, Y Zhou, M Li, L Yu, G Zhang, D Wu and X Qi. Harvesting the fruits of the first stage of the Primate Genome Project. Zoological Research 44, 725. (2023)

13.  Y Zhou, X Zhan, J Jin, L Zhou, J Bergman, X Li, MMC Rousselle, MR Belles, L Zhao, M Fang, J Chen, Q Fang, L Kuderna, T Marques-Bonet, H Kitayama, T Hayakawa, Y-G Yao, H Yang, DN Cooper, X Qi, D-D Wu, MH Schierup and G Zhang. Eighty million years of rapid evolution of the primate Y chromosome. Nature Ecology & Evolution 7, 1114-1130. (2023)

14.  B Zhang, W Chen, Z Wang, W Pang, M Luo, S Wang, Y Shao, W He, Y Deng, L Zhou, J Chen, M Yang, Y Wu, L Wang, H Fernández-Bellon, S Molloy, H Meunier, F Wanert, L Kuderna, T Marques-Bonet, C Roos, X Qi, M Li, Z Liu, MH Schierup, D Cooper, J Liu, Y Zheng, G Zhang and D Wu. Comparative genomics reveals the hybrid origin of a macaque group. Science Advances 9, eadd3580. (2023)

15.  X Bi, L Zhou, J Zhang, S Feng, M Hu, D Cooper, J Lin, J Li, D Wu and G Zhang. Lineage-specific accelerated sequences underlying primate evolution. Science Advances 9, eadc9507. (2023)

16.  Y Shao, L Zhou, F Li, L Zhao, B-L Zhang, F Shao, J-W Chen, C-Y Chen, X Bi, X-L Zhuang, H-L Zhu, J Hu, Z Sun, X Li, D Wang, I Rivas-González, S Wang, Y-M Wang, W Chen, G Li, H-M Lu, Y Liu, LFK Kuderna, KK-H Farh, P-F Fan, L Yu, M Li, Z-J Liu, GP Tiley, AD Yoder, C Roos, T Hayakawa, T Marques-Bonet, J Rogers, PD Stenson, DN Cooper, MH Schierup, Y-G Yao, Y-P Zhang, W Wang, X-G Qi, G Zhang and D-D Wu. Phylogenomic analyses provide insights into primate evolution. Science 380, 913-924. (2023)

17.  I Rivas-González, M Rousselle, F Li, L Zhou, JY Dutheil, K Munch, Y Shao, D Wu, MH Schierup and G Zhang. Pervasive incomplete lineage sorting illuminates speciation and selection in primates. Science 380, eabn4409. (2023)

18.  H Gao, T Hamp, J Ede, JG Schraiber, J Mcrae, M Singer-Berk, Y Yang, ASD Dietrich, PP Fiziev, LFK Kuderna, L Sundaram, Y Wu, A Adhikari, Y Field, C Chen, S Batzoglou, F Aguet, G Lemire, R Reimers, D Balick, MC Janiak, M Kuhlwilm, JD Orkin, S Manu, A Valenzuela, J Bergman, M Rousselle, FE Silva, L Agueda, J Blanc, M Gut, D De Vries, I Goodhead, RA Harris, M Raveendran, A Jensen, IS Chuma, JE Horvath, C Hvilsom, D Juan, P Frandsen, FR De Melo, F Bertuol, H Byrne, I Sampaio, I Farias, JV Do Amaral, M Messias, MNF Da Silva, M Trivedi, R Rossi, T Hrbek, N Andriaholinirina, CJ Rabarivola, A Zaramody, CJ Jolly, J Phillips-Conroy, G Wilkerson, C Abee, JH Simmons, E Fernandez-Duque, S Kanthaswamy, F Shiferaw, D Wu, L Zhou, Y Shao, G Zhang, JD Keyyu, S Knauf, MD Le, E Lizano, S Merker, A Navarro, T Bataillon, T Nadler, CC Khor, J Lee, P Tan, WK Lim, AC Kitchener, D Zinner, I Gut, A Melin, K Guschanski, MH Schierup, RMD Beck, G Umapathy, C Roos, JP Boubli, M Lek, S Sunyaev, A O’donnell-Luria, HL Rehm, J Xu, J Rogers, T Marques-Bonet and KK-H Farh. The landscape of tolerated genetic variation in humans and primates. Science 380, eabn8153. (2023)

19.  LFK Kuderna, H Gao, MC Janiak, M Kuhlwilm, JD Orkin, T Bataillon, S Manu, A Valenzuela, J Bergman, M Rousselle, FE Silva, L Agueda, J Blanc, M Gut, D De Vries, I Goodhead, RA Harris, M Raveendran, A Jensen, IS Chuma, JE Horvath, C Hvilsom, D Juan, P Frandsen, JG Schraiber, FR De Melo, F Bertuol, H Byrne, I Sampaio, I Farias, J Valsecchi, M Messias, MNF Da Silva, M Trivedi, R Rossi, T Hrbek, N Andriaholinirina, CJ Rabarivola, A Zaramody, CJ Jolly, J Phillips-Conroy, G Wilkerson, C Abee, JH Simmons, E Fernandez-Duque, S Kanthaswamy, F Shiferaw, D Wu, L Zhou, Y Shao, G Zhang, JD Keyyu, S Knauf, MD Le, E Lizano, S Merker, A Navarro, T Nadler, CC Khor, J Lee, P Tan, WK Lim, AC Kitchener, D Zinner, I Gut, AD Melin, K Guschanski, MH Schierup, RMD Beck, G Umapathy, C Roos, JP Boubli, J Rogers, KK-H Farh and T Marques Bonet. A global catalog of whole-genome diversity from 233 primate species. Science 380, 906-913. (2023)

20.  X Qi, J Wu, L Zhao, L Wang, X Guang, PA Garber, C Opie, Y Yuan, R Diao, G Li, K Wang, R Pan, W Ji, H Sun, Z Huang, C Xu, AB Witarto, R Jia, C Zhang, C Deng, Q Qiu, G Zhang, C Grueter, D Wu and B Li. Adaptations to a cold climate promoted social evolution in Asian colobine primates. Science 380, eabl8621. (2023)

21.  K Theissinger, C Fernandes, G Formenti, I Bista, PR Berg, C Bleidorn, A Bombarely, A Crottini, GR Gallo, JA Godoy, S Jentoft, J Malukiewicz, A Mouton, RA Oomen, S Paez, PJ Palsbøll, C Pampoulie, MJ Ruiz-López, S Secomandi, H Svardal, C Theofanopoulou, J De Vries, A-M Waldvogel, G Zhang, ED Jarvis, M Bálint, C Ciofi, RM Waterhouse, CJ Mazzoni, J Höglund, SA Aghayan, TS Alioto, I Almudi, N Alvarez, PC Alves, IR Amorim Do Rosario, A Antunes, P Arribas, P Baldrian, G Bertorelle, A Böhne, A Bonisoli-Alquati, LL Boštjančić, B Boussau, CM Breton, E Buzan, PF Campos, C Carreras, LFC Castro, LJ Chueca, F Čiampor, E Conti, R Cook-Deegan, D Croll, MV Cunha, F Delsuc, AB Dennis, D Dimitrov, R Faria, A Favre, OD Fedrigo, R Fernández, GF Ficetola, J-F Flot, T Gabaldón, DR Agius, AM Giani, MTP Gilbert, T Grebenc, K Guschanski, R Guyot, B Hausdorf, O Hawlitschek, PD Heintzman, B Heinze, M Hiller, M Husemann, A Iannucci, I Irisarri, KS Jakobsen, P Klinga, A Kloch, CF Kratochwil, H Kusche, KKS Layton, JA Leonard, E Lerat, G Liti, T Manousaki, T Marques-Bonet, P Matos-Maraví, M Matschiner, F Maumus, AM Mc Cartney, S Meiri, J Melo-Ferreira, X Mengual, MT Monaghan, M Montagna, RW Mysłajek, MT Neiber, V Nicolas, M Novo, P Ozretić, F Palero, L Pârvulescu, M Pascual, OS Paulo, M Pavlek, C Pegueroles, L Pellissier, G Pesole, CR Primmer, A Riesgo, L Rüber, D Rubolini, D Salvi, O Seehausen, M Seidel, B Studer, S Theodoridis, M Thines, L Urban, A Vasemägi, A Vella, N Vella, SC Vernes, C Vernesi, DR Vieites, CW Wheat, G Wörheide, Y Wurm and G Zammit. How genomics can help biodiversity conservation. Trends in Genetics 39, 545-559. (2023)

22.  L Silva, T Mendes, L Ramos, G Zhang and A Antunes. Parallel evolution of fish bi-modal breathing and expansion of olfactory receptor (OR) genes: toward a universal ORs nomenclature. Journal of Genetics and Genomics (2023)

23.  C Shao, S Sun, K Liu, J Wang, S Li, Q Liu, BE Deagle, I Seim, A Biscontin, Q Wang, X Liu, S Kawaguchi, Y Liu, S Jarman, Y Wang, H-Y Wang, G Huang, J Hu, B Feng, C De Pittà, S Liu, R Wang, K Ma, Y Ying, G Sales, T Sun, X Wang, Y Zhang, Y Zhao, S Pan, X Hao, Y Wang, J Xu, B Yue, Y Sun, H Zhang, M Xu, Y Liu, X Jia, J Zhu, S Liu, J Ruan, G Zhang, H Yang, X Xu, J Wang, X Zhao, B Meyer and G Fan. The enormous repetitive Antarctic krill genome reveals environmental adaptations and population insights. Cell 186, 1279-1294.e1219. (2023)

24.  LA Bergeron, S Besenbacher, J Zheng, P Li, MF Bertelsen, B Quintard, JI Hoffman, Z Li, J St. Leger, C Shao, J Stiller, MTP Gilbert, MH Schierup and G Zhang. Evolution of the germline mutation rate across vertebrates. Nature 615, 285-291. (2023)

25.  P Zhang, Y Zhu, Q Guo, J Li, X Zhan, H Yu, N Xie, H Tan, N Lundholm, L Garcia-Cuetos, MD Martin, MA Subirats, Y-H Su, I Ruiz-Trillo, MQ Martindale, J-K Yu, MTP Gilbert, G Zhang and Q Li. On the origin and evolution of RNA editing in metazoans. Cell Reports 42, 112112. (2023)

26.  RR Germain, S Feng, G Chen, GR Graves, JA Tobias, C Rahbek, F Lei, J Fjeldså, PA Hosner, MTP Gilbert, G Zhang and D Nogués-Bravo. Species-specific traits mediate avian demographic responses under past climate change. Nature Ecology & Evolution 7, 862-872. (2023)

27.  RR Germain, S Feng, L Buffan, CP Carmona, G Chen, GR Graves, JA Tobias, C Rahbek, F Lei, J Fjeldså, PA Hosner, MTP Gilbert, G Zhang and D Nogués-Bravo. Changes in the functional diversity of modern bird species over the last million years. Proceedings of the National Academy of Sciences 120, e2201945119. (2023)

28.  K Wanders, G Chen, S Feng, G Zhang, T Székely, M Bruford, Z Végvári, G Eichhorn and A Urrutia. Polygamy and purifying selection in birds. Evolution 77, 276-288. (2023)

29.  G Zhang. The mutation rate as an evolving trait. Nature Reviews Genetics 24, 3-3. (2023)

30.  DD Wu, XG Qi, L Yu, M Li, ZJ Liu, AD Yoder, C Roos, T Hayakawa, J Rogers, T Marques-Bonet, B Su, YG Yao, YP Zhang and G Zhang. Initiation of the Primate Genome Project. Zoological Research 43, 147-149. (2022)

31.  Z Wang, J Zhang, X Xu, C Witt, Y Deng, G Chen, G Meng, S Feng, L Xu, T Szekely, G Zhang and Q Zhou. Phylogeny and sex chromosome evolution of Palaeognathae. Journal of Genetics and Genomics 49, 109-119. (2022)

32.  H Toh, C Yang, G Formenti, K Raja, L Yan, A Tracey, W Chow, K Howe, LA Bergeron, G Zhang, B Haase, J Mountcastle, O Fedrigo, J Fogg, B Kirilenko, C Munegowda, M Hiller, A Jain, D Kihara, A Rhie, AM Phillippy, SA Swanson, P Jiang, DO Clegg, ED Jarvis, JA Thomson, R Stewart, MJP Chaisson and YV Bukhman. A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes. BMC Biology 20, 245. (2022)

33.  B Qiu, X Dai, P Li, RS Larsen, R Li, AL Price, G Ding, MJ Texada, X Zhang, D Zuo, Q Gao, W Jiang, T Wen, L Pontieri, C Guo, K Rewitz, Q Li, W Liu, JJ Boomsma and G Zhang. Canalized gene expression during development mediates caste differentiation in ants. Nature Ecology & Evolution 6, 1753-1765. (2022)

34.  Y Mao and G Zhang. A complete, telomere-to-telomere human genome sequence presents new opportunities for evolutionary genomics. Nature Methods 19, 635-638. (2022)

35.  J Lin, D Duchêne, C Carøe, O Smith, MM Ciucani, J Niemann, D Richmond, AD Greenwood, R Macphee, G Zhang, S Gopalakrishnan and MTP Gilbert. Probing the genomic limits of de-extinction in the Christmas Island rat. Current Biology 32, 1650-1656.e1653. (2022)

36.  Y Li, G Zhang and J Cui. Origin and Deep Evolution of Human Endogenous Retroviruses in Pan-Primates. Viruses 14, 7. (2022)

37.  X Li, R Gao, G Chen, AL Price, DB Øksnebjerg, PA Hosner, Y Zhou, G Zhang and S Feng. Draft genome assemblies of four manakins. Scientific Data 9, 564. (2022)

38.  Q Li, M Wang, P Zhang, Y Liu, Q Guo, Y Zhu, T Wen, X Dai, X Zhang, M Nagel, BH Dethlefsen, N Xie, J Zhao, W Jiang, L Han, L Wu, W Zhong, Z Wang, X Wei, W Dai, L Liu, X Xu, H Lu, H Yang, J Wang, JJ Boomsma, C Liu, G Zhang and W Liu. A single-cell transcriptomic atlas tracking the neural basis of division of labour in an ant superorganism. Nature Ecology & Evolution 6, 1191-1204. (2022)

39.  F Li, RV Rane, V Luria, Z Xiong, J Chen, Z Li, RA Catullo, PC Griffin, M Schiffer, S Pearce, SF Lee, K Mcelroy, A Stocker, J Shirriffs, F Cockerell, C Coppin, CM Sgrò, A Karger, JW Cain, JA Weber, G Santpere, MW Kirschner, AA Hoffmann, JG Oakeshott and G Zhang. Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation. Molecular Ecology Resources 22, 1559-1581. (2022)

40.  HA Lewin, S Richards, E Lieberman Aiden, ML Allende, JM Archibald, M Bálint, KB Barker, B Baumgartner, K Belov, G Bertorelle, ML Blaxter, J Cai, ND Caperello, K Carlson, JC Castilla-Rubio, S-M Chaw, L Chen, AK Childers, JA Coddington, DA Conde, M Corominas, KA Crandall, AJ Crawford, F Dipalma, R Durbin, TE Ebenezer, SV Edwards, O Fedrigo, P Flicek, G Formenti, RA Gibbs, MTP Gilbert, MM Goldstein, JM Graves, HT Greely, IV Grigoriev, KJ Hackett, N Hall, D Haussler, KM Helgen, CJ Hogg, S Isobe, KS Jakobsen, A Janke, ED Jarvis, WE Johnson, SJM Jones, EK Karlsson, PJ Kersey, J-H Kim, WJ Kress, S Kuraku, MKN Lawniczak, JH Leebens-Mack, X Li, K Lindblad-Toh, X Liu, JV Lopez, T Marques-Bonet, S Mazard, JaK Mazet, CJ Mazzoni, EW Myers, RJ O’neill, S Paez, H Park, GE Robinson, C Roquet, OA Ryder, JSM Sabir, HB Shaffer, TM Shank, JS Sherkow, PS Soltis, B Tang, L Tedersoo, M Uliano-Silva, K Wang, X Wei, R Wetzer, JL Wilson, X Xu, H Yang, AD Yoder and G Zhang. The Earth BioGenome Project 2020: Starting the clock. Proceedings of the National Academy of Sciences 119, e2115635118. (2022)

41.  MKN Lawniczak, R Durbin, P Flicek, K Lindblad-Toh, X Wei, JM Archibald, WJ Baker, K Belov, ML Blaxter, T Marques Bonet, AK Childers, JA Coddington, KA Crandall, AJ Crawford, RP Davey, F Di Palma, Q Fang, W Haerty, N Hall, KJ Hoff, K Howe, ED Jarvis, WE Johnson, RN Johnson, PJ Kersey, X Liu, JV Lopez, EW Myers, OV Pettersson, AM Phillippy, MF Poelchau, KD Pruitt, A Rhie, JC Castilla-Rubio, SK Sahu, NA Salmon, PS Soltis, D Swarbreck, F Thibaud-Nissen, S Wang, JL Wegrzyn, G Zhang, H Zhang, HA Lewin and S Richards. Standards recommendations for the Earth BioGenome Project. Proceedings of the National Academy of Sciences 119, e2115639118. (2022)

42.  J Kim, C Lee, BJ Ko, DA Yoo, S Won, AM Phillippy, O Fedrigo, G Zhang, K Howe, J Wood, R Durbin, G Formenti, S Brown, L Cantin, CV Mello, S Cho, A Rhie, H Kim and ED Jarvis. False gene and chromosome losses in genome assemblies caused by GC content variation and repeats. Genome Biology 23, 204. (2022)

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93.  E Lord, N Dussex, M Kierczak, D Díez-Del-Molino, OA Ryder, DWG Stanton, MTP Gilbert, F Sánchez-Barreiro, G Zhang, M-HS Sinding, ED Lorenzen, E Willerslev, A Protopopov, F Shidlovskiy, S Fedorov, H Bocherens, SKSS Nathan, B Goossens, J Van Der Plicht, YL Chan, S Prost, O Potapova, I Kirillova, AM Lister, PD Heintzman, JD Kapp, B Shapiro, S Vartanyan, A Götherström and L Dalén. Pre-extinction Demographic Stability and Genomic Signatures of Adaptation in the Woolly Rhinoceros. Current Biology 30, 3871-3879.e3877. (2020)

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95.  Q Li, Q Guo, Y Zhou, H Tan, T Bertozzi, Y Zhu, J Li, S Donnellan and G Zhang. Construction and sequencing of DNA libraries on Hiseq 2000 platform for the eastern banjo frog. protocols. io (2020)

96.  Q Li, Q Guo, Y Zhou, H Tan, T Bertozzi, Y Zhu, J Li, S Donnellan and G Zhang. Repetitive element annotation for the eastern banjo frog genome assembly V. 3. protocols. io (2020)

97.  KM Kapheim, BM Jones, H Pan, C Li, BA Harpur, CF Kent, A Zayed, P Ioannidis, RM Waterhouse, C Kingwell, E Stolle, A Avalos, G Zhang, WO Mcmillan and WT Wcislo. Developmental plasticity shapes social traits and selection in a facultatively eusocial bee. Proceedings of the National Academy of Sciences 117, 13615-13625. (2020)

98.  J Howe, M Schiøtt, Q Li, Z Wang, G Zhang and JJ Boomsma. A novel method for using RNA-seq data to identify imprinted genes in social Hymenoptera with multiply mated queens. Journal of Evolutionary Biology 33, 1770-1782. (2020)

99.  P Gelabert, M Sandoval-Velasco, A Serres, M De Manuel, P Renom, A Margaryan, J Stiller, T De-Dios, Q Fang, S Feng, S Mañosa, G Pacheco, M Ferrando-Bernal, G Shi, F Hao, X Chen, B Petersen, R-A Olsen, A Navarro, Y Deng, L Dalén, T Marquès-Bonet, G Zhang, A Antunes, MTP Gilbert and C Lalueza-Fox. Evolutionary History, Genomic Adaptation to Toxic Diet, and Extinction of the Carolina Parakeet. Current Biology 30, 108-114.e105. (2020)

100.Q Gao, Z Xiong, RS Larsen, L Zhou, J Zhao, G Ding, R Zhao, C Liu, H Ran and G Zhang. High-quality chromosome-level genome assembly and full-length transcriptome analysis of the pharaoh ant Monomorium pharaonis. GigaScience 9, giaa143. (2020)

101.AK Fotakis, SD Denham, M Mackie, MI Orbegozo, D Mylopotamitaki, S Gopalakrishnan, T Sicheritz-Pontén, JV Olsen, E Cappellini, G Zhang, A Christophersen, MTP Gilbert and ÅJ Vågene. Multi-omic detection of Mycobacterium leprae in archaeological human dental calculus. Philosophical Transactions of the Royal Society B: Biological Sciences 375, 20190584. (2020)

102.AMH Eriksen, H Matthiesen, I Kontopoulos, D Gregory, C Snoeck, G Zhang, MJ Collins and MTP Gilbert. Rapid loss of endogenous DNA in pig bone buried in five different environments. Archaeometry 62, 827-846. (2020)

103.M De Manuel, R Barnett, M Sandoval-Velasco, N Yamaguchi, F Garrett Vieira, ML Zepeda Mendoza, S Liu, MD Martin, M-HS Sinding, SST Mak, C Carøe, S Liu, C Guo, J Zheng, G Zazula, G Baryshnikov, E Eizirik, K-P Koepfli, WE Johnson, A Antunes, T Sicheritz-Ponten, S Gopalakrishnan, G Larson, H Yang, SJ O’brien, AJ Hansen, G Zhang, T Marques-Bonet and MTP Gilbert. The evolutionary history of extinct and living lions. Proceedings of the National Academy of Sciences 117, 10927-10934. (2020)

104.RR Da fonseca, A Couto, AM Machado, B Brejova, CB Albertin, F Silva, P Gardner, T Baril, A Hayward, A Campos, ÂM Ribeiro, I Barrio-Hernandez, H-J Hoving, R Tafur-Jimenez, C Chu, B Frazão, B Petersen, F Peñaloza, F Musacchia, GC Alexander, Jr., H Osório, I Winkelmann, O Simakov, S Rasmussen, MZ Rahman, D Pisani, J Vinther, E Jarvis, G Zhang, JM Strugnell, LFC Castro, O Fedrigo, M Patricio, Q Li, S Rocha, A Antunes, Y Wu, B Ma, R Sanges, T Vinar, B Blagoev, T Sicheritz-Ponten, R Nielsen and MTP Gilbert. A draft genome sequence of the elusive giant squid, Architeuthis dux. GigaScience 9, giz152. (2020)

105.R Barnett, MV Westbury, M Sandoval-Velasco, FG Vieira, S Jeon, G Zazula, MD Martin, SYW Ho, N Mather, S Gopalakrishnan, J Ramos-Madrigal, M De Manuel, ML Zepeda-Mendoza, A Antunes, AC Baez, B De Cahsan, G Larson, SJ O’brien, E Eizirik, WE Johnson, K-P Koepfli, A Wilting, J Fickel, L Dalén, ED Lorenzen, T Marques-Bonet, AJ Hansen, G Zhang, J Bhak, N Yamaguchi and MTP Gilbert. Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens. Current Biology 30, 5018-5025.e5015. (2020)

106.A Avalos, M Fang, H Pan, A Ramirez Lluch, AE Lipka, SD Zhao, T Giray, GE Robinson, G Zhang and ME Hudson. Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies. Proceedings of the National Academy of Sciences 117, 17135-17141. (2020)

107.J Armstrong, G Hickey, M Diekhans, IT Fiddes, AM Novak, A Deran, Q Fang, D Xie, S Feng, J Stiller, D Genereux, J Johnson, VD Marinescu, J Alföldi, RS Harris, K Lindblad-Toh, D Haussler, E Karlsson, ED Jarvis, G Zhang and B Paten. Progressive Cactus is a multiple-genome aligner for the thousand-genome era. Nature 587, 246-251. (2020)

108.L Xu, G Auer, V Peona, A Suh, Y Deng, S Feng, G Zhang, MPK Blom, L Christidis, S Prost, M Irestedt and Q Zhou. Dynamic evolutionary history and gene content of sex chromosomes across diverse songbirds. Nature Ecology & Evolution 3, 834-844. (2019)

109.Y Wang, C Zhang, N Wang, Z Li, R Heller, R Liu, Y Zhao, J Han, X Pan, Z Zheng, X Dai, C Chen, M Dou, S Peng, X Chen, J Liu, M Li, K Wang, C Liu, Z Lin, L Chen, F Hao, W Zhu, C Song, C Zhao, C Zheng, J Wang, S Hu, C Li, H Yang, L Jiang, G Li, M Liu, TS Sonstegard, G Zhang, Y Jiang, W Wang and Q Qiu. Genetic basis of ruminant headgear and rapid antler regeneration. Science 364, eaav6335. (2019)

110.J Stiller and G Zhang. Comparative Phylogenomics, a Stepping Stone for Bird Biodiversity Studies. Diversity 7, 115. (2019)

111.ÂM Ribeiro, L Puetz, NB Pattinson, L Dalén, Y Deng, G Zhang, RR Da Fonseca, B Smit and MTP Gilbert. 31° South: The physiology of adaptation to arid conditions in a passerine bird. Molecular Ecology 28, 3709-3721. (2019)

112.RV Rane, DF Clarke, SL Pearce, G Zhang, AA Hoffmann and JG Oakeshott. Detoxification Genes Differ Between Cactus-, Fruit-, and Flower-Feeding Drosophila. Journal of Heredity 110, 80-91. (2019)

113.H Pan, TL Cole, X Bi, M Fang, C Zhou, Z Yang, DT Ksepka, T Hart, JL Bouzat, LS Argilla, MF Bertelsen, PD Boersma, C-A Bost, Y Cherel, P Dann, SR Fiddaman, P Howard, K Labuschagne, T Mattern, G Miller, P Parker, RA Phillips, P Quillfeldt, PG Ryan, H Taylor, DR Thompson, MJ Young, MR Ellegaard, MTP Gilbert, M-HS Sinding, G Pacheco, LD Shepherd, AJD Tennyson, S Grosser, E Kay, LJ Nupen, U Ellenberg, DM Houston, AH Reeve, K Johnson, JF Masello, T Stracke, B Mckinlay, PG Borboroglu, D-X Zhang and G Zhang. High-coverage genomes to elucidate the evolution of penguins. GigaScience 8, giz117. (2019)

114.I Khan, E Maldonado, L Silva, D Almeida, WE Johnson, SJ O’Brien, G Zhang, ED Jarvis, MTP Gilbert, A Antunes. The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host–Pathogen Arms Race in Birds. Diversity 8, 131. (2019)

115.KM Kapheim, H Pan, C Li, C Blatti, Iii, BA Harpur, P Ioannidis, BM Jones, CF Kent, L Ruzzante, L Sloofman, E Stolle, RM Waterhouse, A Zayed, G Zhang and WT Wcislo. Draft Genome Assembly and Population Genetics of an Agricultural Pollinator, the Solitary Alkali Bee (Halictidae: Nomia melanderi). G3 Genes|Genomes|Genetics 9, 625-634. (2019)

116.Y He, H Pan, G Zhang and S He. Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates. Science China Life Sciences 62, 566-578. (2019)

117.W Gao, Y-B Sun, W-W Zhou, Z-J Xiong, L Chen, H Li, T-T Fu, K Xu, W Xu, L Ma, Y-J Chen, X-Y Xiang, L Zhou, T Zeng, S Zhang, J-Q Jin, H-M Chen, G Zhang, DM Hillis, X Ji, Y-P Zhang and J Che. Genomic and transcriptomic investigations of the evolutionary transition from oviparity to viviparity. Proceedings of the National Academy of Sciences 116, 3646-3655. (2019)

118.S Feng, Q Fang, R Barnett, C Li, S Han, M Kuhlwilm, L Zhou, H Pan, Y Deng, G Chen, A Gamauf, F Woog, R Prys-Jones, T Marques-Bonet, MTP Gilbert and G Zhang. The Genomic Footprints of the Fall and Recovery of the Crested Ibis. Current Biology 29, 340-349.e347. (2019)

119.M Farré, Q Li, Y Zhou, J Damas, LG Chemnick, J Kim, OA Ryder, J Ma, G Zhang, DM Larkin and HA Lewin. A near-chromosome-scale genome assembly of the gemsbok (Oryx gazella): an iconic antelope of the Kalahari desert. GigaScience 8, giy162. (2019)

120.M Farré, J Kim, AA Proskuryakova, Y Zhang, AI Kulemzina, Q Li, Y Zhou, Y Xiong, JL Johnson, PL Perelman, WE Johnson, WC Warren, AV Kukekova, G Zhang, SJ O'brien, OA Ryder, AS Graphodatsky, J Ma, HA Lewin and DM Larkin. Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks. Genome research 29, 576-589. (2019)

121.Y Fan, M Ye, J Y Zhang, L Xu, D Yu, T Gu, Y Yao, J Chen, L Lv, P Zheng, D Wu, G Zhang and Y Yao. Chromosomal level assembly and population sequencing of the Chinese tree shrew genome. Zoological Research 40, 506. (2019)

122.TL Cole, DT Ksepka, KJ Mitchell, AJD Tennyson, DB Thomas, H Pan, G Zhang, NJ Rawlence, JR Wood, P Bover, JL Bouzat, A Cooper, SR Fiddaman, T Hart, G Miller, PG Ryan, LD Shepherd, JM Wilmshurst and JM Waters. Mitogenomes Uncover Extinct Penguin Taxa and Reveal Island Formation as a Key Driver of Speciation. Molecular Biology and Evolution 36, 784-797. (2019)

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124.R Borges, J Fonseca, C Gomes, WE Johnson, SJ O’brien, G Zhang, MTP Gilbert, ED Jarvis and A Antunes. Avian Binocularity and Adaptation to Nocturnal Environments: Genomic Insights from a Highly Derived Visual Phenotype. Genome Biology and Evolution 11, 2244-2255. (2019)

125.G Zhang. The first AsiaEvo conference, connecting Asian evolutionary biologists to the world. National Science Review 5, 614-616. (2018)

126.G Zhang. The bird’s-eye view on chromosome evolution. Genome Biology 19, 201. (2018)

127.C Zhang, L Chen, Y Zhou, K Wang, LG Chemnick, OA Ryder, W Wang, G Zhang and Q Qiu. Draft genome of the milu (Elaphurus davidianus). GigaScience 7, gix130. (2018)

128.ML Zepeda Mendoza, Z Xiong, M Escalera-Zamudio, AK Runge, J Thézé, D Streicker, HK Frank, E Loza-Rubio, S Liu, OA Ryder, JA Samaniego Castruita, A Katzourakis, G Pacheco, B Taboada, U Löber, OG Pybus, Y Li, E Rojas-Anaya, K Bohmann, A Carmona Baez, CF Arias, S Liu, AD Greenwood, MF Bertelsen, NE White, M Bunce, G Zhang, T Sicheritz-Pontén and MPT Gilbert. Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat. Nature Ecology & Evolution 2, 659-668. (2018)

129.RL Rogers, L Zhou, C Chu, R Márquez, A Corl, T Linderoth, L Freeborn, MD Macmanes, Z Xiong, J Zheng, C Guo, X Xun, MR Kronforst, K Summers, Y Wu, H Yang, CL Richards-Zawacki, G Zhang and R Nielsen. Genomic Takeover by Transposable Elements in the Strawberry Poison Frog. Molecular Biology and Evolution 35, 2913-2927. (2018)

130.H Rando, M Farré, M Robson, N Won, J Johnson, R Buch, E Bastounes, X Xiang, S Feng, S Liu, Z Xiong, J Kim, G Zhang, L Trut, D Larkin, A Kukekova. Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly. Genes 9, 308. (2018).

131.B Qiu, RS Larsen, N-C Chang, J Wang, JJ Boomsma and G Zhang. Towards reconstructing the ancestral brain gene-network regulating caste differentiation in ants. Nature Ecology & Evolution 2, 1782-1791. (2018)

132.C Liu, Y Zhang, Y Ren, H Wang, S Li, F Jiang, L Yin, X Qiao, G Zhang, W Qian, B Liu and W Fan. The genome of the golden apple snail Pomacea canaliculata provides insight into stress tolerance and invasive adaptation. GigaScience 7, giy101. (2018)

133.HA Lewin, GE Robinson, WJ Kress, WJ Baker, J Coddington, KA Crandall, R Durbin, SV Edwards, F Forest, MTP Gilbert, MM Goldstein, IV Grigoriev, KJ Hackett, D Haussler, ED Jarvis, WE Johnson, A Patrinos, S Richards, JC Castilla-Rubio, M-A Van Sluys, PS Soltis, X Xu, H Yang and G Zhang. Earth BioGenome Project: Sequencing life for the future of life. Proceedings of the National Academy of Sciences 115, 4325-4333. (2018)

134.AV Kukekova, JL Johnson, X Xiang, S Feng, S Liu, HM Rando, AV Kharlamova, Y Herbeck, NA Serdyukova, Z Xiong, V Beklemischeva, K-P Koepfli, RG Gulevich, AV Vladimirova, JP Hekman, PL Perelman, AS Graphodatsky, SJ O’brien, X Wang, AG Clark, GM Acland, LN Trut and G Zhang. Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours. Nature Ecology & Evolution 2, 1479-1491. (2018)

135.Y Yang, Y Wang, Y Zhao, X Zhang, R Li, L Chen, G Zhang, Y Jiang, Q Qiu, W Wang, H-J Wei and K Wang. Draft genome of the Marco Polo Sheep (Ovis ammon polii). GigaScience 6, gix106. (2017)

136.C Shao, B Bao, Z Xie, X Chen, B Li, X Jia, Q Yao, G Ortí, W Li, X Li, K Hamre, J Xu, L Wang, F Chen, Y Tian, AM Schreiber, N Wang, F Wei, J Zhang, Z Dong, L Gao, J Gai, T Sakamoto, S Mo, W Chen, Q Shi, H Li, Y Xiu, Y Li, W Xu, Z Shi, G Zhang, DM Power, Q Wang, M Schartl and S Chen. The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry. Nature Genetics 49, 119-124. (2017)

137.R Seki, C Li, Q Fang, S Hayashi, S Egawa, J Hu, L Xu, H Pan, M Kondo, T Sato, H Matsubara, N Kamiyama, K Kitajima, D Saito, Y Liu, MTP Gilbert, Q Zhou, X Xu, T Shiroishi, N Irie, K Tamura and G Zhang. Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features. Nature Communications 8, 14229. (2017)

138.SST Mak, S Gopalakrishnan, C Carøe, C Geng, S Liu, M-HS Sinding, LFK Kuderna, W Zhang, S Fu, FG Vieira, M Germonpré, H Bocherens, S Fedorov, B Petersen, T Sicheritz-Pontén, T Marques-Bonet, G Zhang, H Jiang and MTP Gilbert. Comparative performance of the BGISEQ-500 vs Illumina HiSeq2500 sequencing platforms for palaeogenomic sequencing. GigaScience 6, gix049. (2017)

139.H Hu, M Uesaka, S Guo, K Shimai, T-M Lu, F Li, S Fujimoto, M Ishikawa, S Liu, Y Sasagawa, G Zhang, S Kuratani, J-K Yu, TG Kusakabe, P Khaitovich, N Irie and EC The. Constrained vertebrate evolution by pleiotropic genes. Nature Ecology & Evolution 1, 1722-1730. (2017)

140.AD Hargreaves, L Zhou, J Christensen, F Marlétaz, S Liu, F Li, PG Jansen, E Spiga, MT Hansen, SVH Pedersen, S Biswas, K Serikawa, BA Fox, WR Taylor, JF Mulley, G Zhang, RS Heller and PWH Holland. Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster. Proceedings of the National Academy of Sciences 114, 7677-7682. (2017)

141.J Gao, Q Li, Z Wang, Y Zhou, P Martelli, F Li, Z Xiong, J Wang, H Yang and G Zhang. Sequencing, de novo assembling, and annotating the genome of the endangered Chinese crocodile lizard Shinisaurus crocodilurus. GigaScience 6, gix041. (2017)

142.JJ Boomsma, SG Brady, RR Dunn, J Gadau, J Heinze, L Keller, CS Moreau, NJ Sanders, L Schrader

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143.A Avalos, H Pan, C Li, JP Acevedo-Gonzalez, G Rendon, CJ Fields, PJ Brown, T Giray, GE Robinson, ME Hudson and G Zhang. A soft selective sweep during rapid evolution of gentle behaviour in an Africanized honeybee. Nature Communications 8, 1550. (2017)

144.W Yin, Z Wang, Q Li, J Lian, Y Zhou, B Lu, L Jin, P Qiu, P Zhang, W Zhu, B Wen, Y Huang, Z Lin, B Qiu, X Su, H Yang, G Zhang, G Yan and Q Zhou. Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper. Nature Communications 7, 13107. (2016)

145.Z Xiong, F Li, Q Li, L Zhou, T Gamble, J Zheng, L Kui, C Li, S Li, H Yang and G Zhang. Draft genome of the leopard gecko, Eublepharis macularius. GigaScience 5, s13742-13016-10151-13744. (2016)

146.Z Wang, J Lian, Q Li, P Zhang, Y Zhou, X Zhan and G Zhang. RES-Scanner: a software package for genome-wide identification of RNA-editing sites. GigaScience 5, s13742-13016-10143-13744. (2016)

147.H Pan, H Yu, V Ravi, C Li, AP Lee, MM Lian, B-H Tay, S Brenner, J Wang, H Yang, G Zhang and B Venkatesh. The genome of the largest bony fish, ocean sunfish (Mola mola), provides insights into its fast growth rate. GigaScience 5, s13742-13016-10144-13743. (2016)

148.S Nygaard, H Hu, C Li, M Schiøtt, Z Chen, Z Yang, Q Xie, C Ma, Y Deng, RB Dikow, C Rabeling, DR Nash, WT Wcislo, SG Brady, TR Schultz, G Zhang and JJ Boomsma. Reciprocal genomic evolution in the ant–fungus agricultural symbiosis. Nature Communications 7, 12233. (2016)

149.JP Machado, WE Johnson, MTP Gilbert, G Zhang, ED Jarvis, SJ O’brien and A Antunes. Bone-associated gene evolution and the origin of flight in birds. BMC Genomics 17, 371. (2016)

150.D Almeida, E Maldonado, I Khan, L Silva, MTP Gilbert, G Zhang, ED Jarvis, SJ O’brien, WE Johnson and A Antunes. Whole-Genome Identification, Phylogeny, and Evolution of the Cytochrome P450 Family 2 (CYP2) Subfamilies in Birds. Genome Biology and Evolution 8, 1115-1131. (2016)

151.J Zhang, C Li, Q Zhou and G Zhang. Improving the ostrich genome assembly using optical mapping data. GigaScience 4, s13742-13015-10062-13749. (2015)

152.G Zhang. Bird sequencing project takes off. Nature 522, 34-34. (2015)

153.L Yan, X Wang, H Liu, Y Tian, J Lian, R Yang, S Hao, X Wang, S Yang, Q Li, S Qi, L Kui, M Okpekum, X Ma, J Zhang, Z Ding, G Zhang, W Wang, Y Dong and J Sheng. The Genome of Dendrobium officinale Illuminates the Biology of the Important Traditional Chinese Orchid Herb. Molecular Plant 8, 922-934. (2015)

154.Y Sun, Z Xiong, X Xiang, S Liu, W Zhou, X Tu, L Zhong, L Wang, D Wu, B Zhang, C Zhu, M Yang, H Chen, F Li, L Zhou, S Feng, C Huang, G Zhang, D Irwin, DM Hillis, RW Murphy, H Yang, J Che, J Wang and Y Zhang. Whole-genome sequence of the Tibetan frog Nanorana parkeri and the comparative evolution of tetrapod genomes. Proceedings of the National Academy of Sciences 112, E1257-E1262. (2015)

155.J Pereira, WE Johnson, SJ O’brien, ED Jarvis, G Zhang, MTP Gilbert, V Vasconcelos and A Antunes. Evolutionary Genomics and Adaptive Evolution of the Hedgehog Gene Family (Shh, Ihh and Dhh) in Vertebrates. PLOS ONE 9, e74132. (2015)

156.M Parks, S Subramanian, C Baroni, MC Salvatore, G Zhang, CD Millar and DM Lambert. Ancient population genomics and the study of evolution. Philosophical Transactions of the Royal Society B: Biological Sciences 370, 20130381. (2015)

157.K Nadachowska-Brzyska, C Li, L Smeds, G Zhang and H Ellegren. Temporal Dynamics of Avian Populations during Pleistocene Revealed by Whole-Genome Sequences. Current Biology 25, 1375-1380. (2015)

158.X Li, D Fan, W Zhang, G Liu, L Zhang, L Zhao, X Fang, L Chen, Y Dong, Y Chen, Y Ding, R Zhao, M Feng, Y Zhu, Y Feng, X Jiang, D Zhu, H Xiang, X Feng, S Li, J Wang, G Zhang, MR Kronforst and W Wang. Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies. Nature Communications 6, 8212. (2015)

159.J Korb, M Poulsen, H Hu, C Li, JJ Boomsma, G Zhang and J Liebig. A genomic comparison of two termites with different social complexity. Frontiers in Genetics 6, (2015)

160.I Khan, Z Yang, E Maldonado, C Li, G Zhang, MTP Gilbert, ED Jarvis, SJ O’brien, WE Johnson and A Antunes. Olfactory Receptor Subgenomes Linked with Broad Ecological Adaptations in Sauropsida. Molecular Biology and Evolution 32, 2832-2843. (2015)

161.KM Kapheim, H Pan, C Li, SL Salzberg, D Puiu, T Magoc, HM Robertson, ME Hudson, A Venkat, BJ Fischman, A Hernandez, M Yandell, D Ence, C Holt, GD Yocum, WP Kemp, J Bosch, RM Waterhouse, EM Zdobnov, E Stolle, FB Kraus, S Helbing, RFA Moritz, KM Glastad, BG Hunt, MaD Goodisman, F Hauser, CJP Grimmelikhuijzen, DG Pinheiro, FMF Nunes, MPM Soares, ÉD Tanaka, ZLP Simões, K Hartfelder, JD Evans, SM Barribeau, RM Johnson, JH Massey, BR Southey, M Hasselmann, D Hamacher, M Biewer, CF Kent, A Zayed, C Blatti, S Sinha, JS Johnston, SJ Hanrahan, SD Kocher, J Wang, GE Robinson and G Zhang. Genomic signatures of evolutionary transitions from solitary to group living. Science 348, 1139-1143. (2015)

162.ED Jarvis, S Mirarab, AJ Aberer, B Li, P Houde, C Li, SYW Ho, BC Faircloth, B Nabholz, JT Howard, A Suh, CC Weber, RR Da Fonseca, A Alfaro-Núñez, N Narula, L Liu, D Burt, H Ellegren, SV Edwards, A Stamatakis, DP Mindell, J Cracraft, EL Braun, T Warnow, W Jun, MTP Gilbert, G Zhang and C The Avian Phylogenomics. Phylogenomic analyses data of the avian phylogenomics project. GigaScience 4, s13742-13014-10038-13741. (2015)

163.A Georges, Q Li, J Lian, D O’meally, J Deakin, Z Wang, P Zhang, M Fujita, HR Patel, CE Holleley, Y Zhou, X Zhang, K Matsubara, P Waters, JaM Graves, SD Sarre and G Zhang. High-coverage sequencing and annotated assembly of the genome of the Australian dragon lizard Pogona vitticeps. GigaScience 4, s13742-13015-10085-13742. (2015)

164.L Eöry, MTP Gilbert, C Li, B Li, A Archibald, BL Aken, G Zhang, E Jarvis, P Flicek and DW Burt. Avianbase: a community resource for bird genomics. Genome Biology 16, 21. (2015)

165.Y Dong, X Zhang, M Xie, B Arefnezhad, Z Wang, W Wang, S Feng, G Huang, R Guan, W Shen, R Bunch, R Mcculloch, Q Li, B Li, G Zhang, X Xu, JW Kijas, GH Salekdeh, W Wang and Y Jiang. Reference genome of wild goat (capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication. BMC Genomics 16, 431. (2015)

166.P Dobrynin, S Liu, G Tamazian, Z Xiong, AA Yurchenko, K Krasheninnikova, S Kliver, A Schmidt-Küntzel, K-P Koepfli, W Johnson, LFK Kuderna, R García-Pérez, MD Manuel, R Godinez, A Komissarov, A Makunin, V Brukhin, W Qiu, L Zhou, F Li, J Yi, C Driscoll, A Antunes, TK Oleksyk, E Eizirik, P Perelman, M Roelke, D Wildt, M Diekhans, T Marques-Bonet, L Marker, J Bhak, J Wang, G Zhang and SJ O’brien. Genomic legacy of the African cheetah, Acinonyx jubatus. Genome Biology 16, 277. (2015)

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刘薇薇  副研究员  liuweiwei@mail.kiz.ac.cn
赵若苹  高级实验师  zhaorp@mail.kiz.ac.cn
赵  洁  实验师  zhaojie@mail.kiz.ac.cn


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张霞芳  2019级博士研究生  zhangxiafang@mail.kiz.ac.cn  
左大双  2021级博士研究生  zdas998@163.com
杞燕梅  2022级博士研究生  q18277328703@126.com
钟文江  2024级博士研究生  zhongwenjiang@mail.kiz.ac.cn
王  娇   2022级硕士研究生  2650471212@qq.com


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