研究员，博士生导师，长期从事脑进化发育遗传机制及脑功能和脑疾病机理研究，相关成果作为第一或通讯作者（含共同）发表于Nature Communications、Science Advances、PNAS等国际学术期刊，先后入选中国科学院“率先行动”引才计划、云南省“云岭英才”高层次人才和云南省享受政府特殊津贴专家。

经历

1999.09-2003.07  学士，南开大学生命科学学院

2003.09-2011.01  博士，中国科学院上海生物化学与细胞生物学研究所

2011.08-2017.07  博士后，美国加州大学旧金山分校（UCSF）

2017.08-至今     研究员，中国科学院昆明动物研究所

方向一：大脑新皮层进化发育遗传机制

大脑新皮层和胼胝体分别是哺乳动物和胎盘哺乳动物的创新性性状，我们将以爬行类、有袋类和胎盘类代表性物种为研究对象，结合单细胞多组学、进化生物学、发育生物学等研究方法手段，阐明其进化发育的细胞机制和遗传基础。

方向二：脑-体轴的神经调控与适应性进化

大脑可以通过与外周器官的直接神经投射连接，参与其生理功能调节和病理过程，我们将利用神经生物学和分子细胞生物学等研究手段，解析不同物种脑-体轴神经投射的异同，以及在适应性行为调节中的作用。

方向三：神经发育障碍的致病机理

神经细胞发育异常和神经连接活性紊乱，是智力障碍等神经发育障碍的重要致病因素，我们将构建相关疾病动物模型，结合神经电生理、发育生物学和分子细胞生物学等手段，阐明关键致病因子的作用机理，探索相关疾病治疗手段。

发表论文总数:  35/通讯作者论文数：12

近5年内发表的代表性论文/专著

1.    Wan LP^#, Li Y^#, Zhao S, Zhao S, Song NN, Yuan KM, Yang C, Ding YQ, Mao B^*, Sheng N^*, Tao W^*, Ma P^*. The pathogenic factor of ZC4H2-associated rare disorder is a postsynaptic regulator for synaptic activity and cognitive function. PNAS (2025) 122(28):e2426375122.

2.    Ye Y, Jin B, Zhang HW, Sheng N^*. Strategies for Dissecting the Genetic Driving of Conserved Noncoding-Elements for Evolutionary Development of the Corpus Callosum. Neuroscience Bulletin (2024) 40(7):1025-1027.

3.    Li Y, Wan LP, Song NN, Ding YQ, Zhao S, Niu J, Mao B^*, Sheng N^*, Ma P^*. RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination. Science Advances (2024) 10(6):eadk3931.

4.    Zhuang XL^#, Zhang JJ^#, Shao Y^#, Ye Y^#, Chen CY^#, Zhou L^#, Wang ZB^#, Luo X, Su B, Yao YG, Cooper DN, Hu BX, Wang L, Qi XG, Lin J, Zhang GJ^*, Wang W^*, Sheng N^*, Wu DD^*. Integrative omics reveals rapidly evolving regulatory sequences driving primate brain evolution. Molecular Biology and Evolution (2023) 40(8):msad173.

5.    Ma P^#, Wan LP^#, Li Y^#, He CH^#, Song NN, Zhao S, Wang H, Ding YQ^*, Mao B^*, Sheng N^*. RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission. Science Advances (2022) 8(39):eabq4736.

其他代表性论文/专著

1.    Yuan KM, Shi YS^*, Sheng N^*. A new immunomodulatory strategy for perioperative neurocognitive disorders: repurposing ceftriaxone. Neuroscience (2025). 15;591:116-117.

2.    Xu L, Yu D, Xu M, Liu Y, Yang LX, Zou QC, Feng XL, Li MH, Sheng N^*, Yao YG^*. Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2. EBioMedicine (2024) 107:105281.

3.    Wu Y, Bi R, Zeng C, Ma C, Sun C, Li J, Xiao X, Li M, Zhang DF, Zheng P, Sheng N^*, Luo XJ^*, Yao YG^*. Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci. EBioMedicine (2019) 44:530-541.

4.    Duan GF, Ye Y, Xu S, Tao W, Zhao S, Jin T, Nicoll RA, Shi YS^*, Sheng N^*. Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain. Nature Communications (2018) 9(1):4879.

5.    Sheng N^*, Bemben MA, Díaz-Alonso J, Tao W, Shi YS, Nicoll RA^*. LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes. PNAS (2018) 115(15):3948-3953.

6.    Sheng N, Shi YS, Nicoll RA^*. Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking. PNAS (2017) 114(5):1159-1164.

7.    Sheng N, Shi YS, Lomash RM, Roche KW, Nicoll RA^*. Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1. Elife (2015) 3:e11682.

8.    Sheng N, Xie Z, Wang C, Bai G, Zhang K, Zhu Q, Song J, Guillemot F, Chen YG, Lin A, Jing N^*. Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1. PNAS (2010) 107(44):18886-18891.