简历

中国科学院昆明动物研究所，模式动物表型与遗传研究国家重大科技基础设施（灵长类设施），副研究员，硕士生导师。

主要从事灵长类动物脑疾病模型构建和表型评价及转化研究。包括：1）构建物理化学诱导缺血性脑卒中猕猴模型，PCP诱导拟精神分裂症猕猴模型，吗啡依赖记忆异常猕猴模型等，并进行模型相关技术和转化研究；2）采用生理病理、脑影像、行为学、代谢组学等多模态技术手段，分析孤独症基因编辑、自发基因突变、自发自伤、自发高血糖等猕猴模型的表型特征及生物标记物；3）负责灵长类设施交互式行为分析模块，发展猕猴交互式行为、认知功能、基础行为等不同层次的表型测试，为猕猴脑疾病模型治疗策略研究提供技术和平台；4）开发具自主原创性、可精确评价猕猴行为特征的检测技术，重点构建AI辅助的灵长类动物精细行为分析系统和社交行为鉴定范式，评价猕猴脑疾病损伤及修复、社交障碍等行为特征。

先后主持多项国家自然科学基金面上项目、国家基金国际(地区)合作与交流项目，课题骨干负责子课题参与科技创新2030“脑科学与类脑研究”重大项目、科技部国家重点研发计划、“973” 子课题等；主持云南省重点项目、中科院知识创新工程重要方向、中科院“西部之光”等项目。共发表论文70余篇，h-index=22，其中30余篇以灵长类动物为实验对象，发表杂志包括Circulation、Addiction Biology和NeuroImage等。撰写、翻译、第二主编出版科普书籍、教科书等5本。申请/授权国家发明专利多项。独立培养10余名硕士研究生，联合培养10余名博士研究生和硕士研究生，10余名技术人员。2015年被评为云南省中青年学术和技术带头人。

学习和工作经历

教育经历

2007/08，中国科学院研究生院，动物学，博士。

1990/07，北京师范大学，生物系，理学学士。

工作经历

2014/08 - 2014/11，俄罗冈健康与科学大学行为神经生物学实验室，高级访问学者。

2010/09 – 2011/06，法国巴黎居里大学，发育分子和细胞生物学实验室，博后。

2008/12 – 2009/06，德国柏林自由大学，神经生物—生物学研究所，行为神经生物学实验室，高级访问学者。

2002/03 - 2003/03，澳大利亚墨尔本大学—维多利亚精神卫生研究所，行为神经生物学实验室，访问学者。

1990/07 - 至今，中国科学院昆明动物研究所，认知障碍病理组和灵长类设施。

1）构建灵长类动物社交行为实验范式和测量技术，采用多模态手段，结合AI分析、评估孤独症等神经精神疾病猕猴的社交障碍表型特征，为干预治疗研究奠定基础。

2）灵长类动物脑疾病模型构建和转化研究：优化灵长类动物缺血性脑卒中模型，研究其修复机制。

主要科研工作及成果：在NeuroImage，Addiction Biology, Brain Research等国际学术刊物上发表SCI文章60余篇。 

1. Zhang BL, Zhang BL, Chen YX, Zhang YL, Qiao YC, Wu Y, Zhang Y, Lu YZ, You XR, Li YL, Huang HD, Wang Q, Li YJ, Wang Y, Xiao WX, Duan HX, Yu XM, Yang MM, Lv LB, Cooper DN, Zheng P, Yao YG, Liu N*, Wang JH*, Wu DD*. Forward and reverse genomic screens enhance the understanding of phenotypic variation in a large Chinese rhesus macaque cohort. 2024, DOI: 10.21203/rs.3.rs-4800799/v1, preprint.

2. Huang HD, Pu JL, Zhou YF, Fan Y, Zhang YL, Li YL, Chen YZ, Wang Y, Yu XM, Bulgin D, Zhou Z*, Wang JH*. A spontaneoushyperglycemic cynomolgus monkey presentscognitive deficits, neurological dysfunction and cataract. Clin Exp Pharmacol Physiol, 2024;51:e13863.

3. Wei ZH , Liu YJ ,Liu SJ, Yu XM, Zhang HR, Zhu T, Zhang B, Zhang YL, Huang HD, Fan Y, Li HL, Wang JH*, Tian J*, Hui H*. First Non-human primate-sized magnetic particle imaging system based on digital-scanned focus field. IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, 2024, VOL. 73, 5023611..

4. Zhang Z, Huang YC, Chen XY, Li JH, Yang Y, Lv LB, Wang JH, Wang MY, Wang YW, Wang Z. State-specific regulation of electrical stimulation in the intralaminar thalamus of macaque monkeys: network and transcriptional insights into arousal, Advanced Science, 2024 Jun 27:e2402718. doi: 10.1002/advs.202402718. 

5. Bin Li, Wen Xi, Ying Bai, Xue Liu, Yuan Zhang, Lu Li, Liang Bian, Chenchen Liu, Ying Tang, Ling Shen, Li Yang, Xiaochun Gu, Jian Xie, Zhongqiu Zhou, Yu Wang, Xiaoyu Yu, Jianhong Wang, Jie Chao, Bing Han, Honghong Yao. FTO-dependent m6 A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke, Nature communications, 2023, 14(489).

6. Huang H#, Zhang B#, Zheng SY, Li CY, Zhu XG*, Wang JH*. The effects of aging and dopaminergic inhibition on large scale maze learning in rhesus monkeys. Brain Research Bulletin, 2021. 175:63-68.

7. Zhang ZT#, Wang SG#, Du LL#, Xu L, Lin Y, Liu KZ, Zou YH, Li B, Ye QQ, Mao Y, Chen WX, Zhou GP, Sun HY, Huang H, Li R, Li G, Li LH, Wang Q, Long QW, Huang HD, Geng X, Liu Y, Liu CR, Li B*, Zhou Z*, Li JH*, Wang JH*. A pilot behavioural and neuroimaging investigation on photothrombotic stroke models in Rhesus monkeys. Journal of Neuroscience Methods, 2021, 362:109291.

8. Ge LJ#*, Yang FH#, Li W, Wang T, Lin Y, Feng J, Chen NH, Jiang M, Wang JH*, Hu XT*, Chen G*. In vivo neuroregeneration to treat ischemic stroke in adult non-human primate brains through neuroD1 AAV-based gene therapy, Frontiers in Cell and Developmental Biology, 2020, 8: 590008.

9. Yang L#, Han B#, Zhang ZT, Wang SG, Bai Y, Zhang Y, Tang Y, Du LL, Xu L, Wu FF, Zuo L, Chen XF, Lin Y, Liu KZ, Ye QQ, Chen BL, Li B, Tang TC, Wang Y, Shen L, Wang GT, Ju MZ, Yuan MQ, Jiang W, Zhang JH, Hu G, Wang JH* and Yao HH*. Extracellular vesicle-mediated delivery of circSCMH1 promotes functional recovery in rodent and nonhuman primate ischemic stroke models. Circulation，2020，142(6):556-574.

10. Zhang B, Xiong F, Ma YY, Li B, Mao Y, Zhou Z, Yu HL, Li JH, Li CY, Fu J,  Wang JH*, Zhao XD*, Chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys, Psychopharmacology, 2019, Jul;236(7):2223-2232.

11. Dai PM, Huang H, Zhang L, He J, Yang FH, Ge LJ, Lin Y, Yu HL*, Wang JH*. A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys. Scientific Reports, 2017, Mar 30;7:45097. doi: 10.1038/srep45097.

12. Zhang Y, Zong W, Zhang L, Ma YY, Wang JH*. Protein kinase M ζ and the maintenance of long-term memory. Neurochemistry International, 2016, 99:215-20.

13. Wu XJ, Zhao N, Li CY, Liu CR, Wei JK, Zong W, Bai F, Yang LX, Ryabinin AE,  Ma YY*, Wang JH*. Morphine-induced conditioned place preference in rhesus monkeys: resistance to inactivation of insula and extinction. Neurobiology of Learning and Memory, 2016, 131: 192–200.

14. Liu CR, Tian XG, Liu HL, Mo Y, Bai F, Zhao XD, Ma YY, Wang JH*. Rhesus monkey brain development during late infancy and the effect of phencyclidine: A longitudinal MRI and DTI study. NeuroImage. 2015 Feb 15;107:65-75.

15. Sun YM, Zong W, Zhou MR, Ma YY*, Wang JH*. Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine. Pharmacology Biochemistry and Behavior. 2015, 135, 60–63.

16. Chen YM, Liu XF, Jia X, Zong W, Ma YY, Xu FQ*, Wang JH*. Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice. Behav Brain Res. 2014 Sep 1;275C:219-224.

17. Hu YZ, Jiang HH, Liu CR, Wang JH*, Yu CY, Carlson S*, Saarinen V, Rizak J, Tian XG, Tan H, Chen ZY, Ma YY, Hu XT. What interests them in the pictures? -- The difference in eye tracking between rhesus monkeys and humans. Neuroscience Bulletin, 2013, 29(5):553-64.

18. Wang JH*, Rizak JD, Chen YM, Li L, Hu XT, Ma YY. Interactive effects of morphine and dopaminergic compounds on spatial working memory in rhesus monkeys. Neuroscience Bulletin, 2013, 29(1): 37–46.

19. Wang JH*, Chen YM, Carlson S, Li L, Hu XT, Ma YY. Interactive effects of morphine and scopolamine, MK-801，propanolol on spatial working memory in rhesus monkeys. Neuroscience Letters, 2012, 15;523(2):119-24.

20. Feng XL, Wang LN, Yang SC, Qin DD, Wang JH, Li CL, Lv LB, Ma YY, Hu XT. Maternal separation produces lasting changes in cortisol and behavior in rhesus monkeys. PNAS, 2011http://www.pnas.org/content/early/2011/08/12/1010943108.full.pdf+html.

21. Wang JH*, Wu XJ, Li CY, Wei JK, Jiang HH, Liu CR, Yu CY, Carlson S, Hu XT, Duan W, Ma YY*. Effect of morphine on conditioned place preference in rhesus monkeys. Addiction Biology, 2012 May;17(3):539-46.

22. Zhang J, He J, Chen YM, Wang JH*, Ma YY*. Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory. Brain Research. 2008, 1230：150-157.  

23. Wang JH, Zhang B, Meng ZQ, Sun NL, Ma MX, Zhang XH, Tang XD, Sanford LD,  Wilson AWF, Hu XT, Carlson S, Ma YY. Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey. Dev Neurobiol.（Journal of Neurobiology), 2007, 67(13):1731-41.

24. Wang JH, Liu XF, Chen YM, Wang HY, Sun HY, Fu Y, Carlson S, Ma YY, Wilson A.W. F. Heroin impairs map/picture following and memory tasks dependent on gender and orientation of the tasks. Behav. Neurosci. 2007, 121(4):653-64.

25. Ma MX, Chen YM, He J, Zeng T, Wang JH*. Effects of morphine and withdrawal on Y-maze spatial recognition memory in mice: state- and dose- dependent. Neuroscience. 2007, 29;147(4):1059-65.

26. Wang JH, Ma YY, Buuse van den M. Improved spatial recognition memory in mice lacking the adenosine A_2A receptors. Experimental Neurology, 2006,199(2):438-45.

27. Wang JH, Fu Y, Wilson F, Ma YY. Ketamine affects memory consolidation: differential effects in T-maze and passive avoidance paradigms in mice. Neuroscience. 2006, 140:993-1002. 

28. Wang JH, Yang JZ, Wilson F, Ma YY. Differently lasting effects of prenatal and postnatal chronic clozapine/haloperidol on activity and memory in mouse offspring. Pharmacology, Biochemistry and Behavior, 2006, 84(3):468-478.

29. Wang JH, Cai JX, Ma YY. Effect of stress on memory process in a passive avoidance paradigm. Neurology, Psychiatry and Brain Research, 2004, 11: 103-108.

30. Wang JH, Short J, Ledent C, Andrew J L, Buuse ven den M. Reduced startle habituation and prepulse inhibition in mice lacking the adenosine A_2A receptor. Behavioral Brain Research. 2003,14,143(2):201-7.

31. Wang JH, Buuse ven den M, Tian SW，Ma YY. Effect of paradoxical sleep deprivation and stress on passive avoidance behavior. Physiology and Behavior. 2003，79:516-519.