简历

理学博士、硕士生导师。从事“精神疾病的遗传机理和分子机制”研究。以第一作者/共同第一作者身份在Brain、Molecular Psychiatry、Nature Communications、Advanced Science、Translational Psychiatry等期刊发表论文多篇，先后主持国家自然科学基金委面上项目，中国科学院特别研究助理项目，云南省基础研究计划“优秀青年”项目，入选“兴滇英才支持计划”青年人才和项目支持。

工作经历

(1) 2021-04至今，中国科学院昆明动物研究所，副研究员

(2) 2021-01至2021-04，中国科学院昆明动物研究所，助理研究员

(3) 2015-09至2017-09，中国科学院昆明动物研究所，研究实习员

学习经历

(1) 2017-09至2021-01，中国科学院大学，神经生物学，博士

(2) 2012-09至2015-06，昆明理工大学，制药工程，硕士

(3) 2008-09至2012-06，湘南学院，药学，学士

①利用细胞及动物模型解析精神疾病易感机制

②探索低氧环境重塑脑认知功能的神经机制

（1）国家自然科学基金委面上项目，精神分裂症风险区域2q33.1在疾病中遗传机制及致病机理研究，2022.1-2025.12，55万，主持；

（2）云南省基础研究计划“优秀青年”项目，NEGR1基因影响抑郁症的发病机制研究，2023.4-2026.3，30万，主持；

（3）国家自然科学基金委区域联合重点项目，基于精神分裂症临床队列的免疫组学异常特征及其生物标记物的研究，2023.1-2026.12，255万，核心参与。

2020年，荣获中国科学院院长奖优秀奖

2020年，荣获博士研究生国家奖学金

2019年，荣获中国科学院大学朱李月华奖学金

(1) Yongxia Huo^#, Shiwu Li^#, Jiewei Liu, Xiaoyan Li, Xiongjian Luo*. Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk, Nature Communications, 2019, 10(1):670.  

(2) Shiwu Li^#, Yifan Li^#, Xiaoyan Li, Jiewei Liu, Yongxia Huo, Junyang Wang, Zhongchun Liu, Ming Li, Xiongjian Luo*. Regulatory mechanisms of major depressive disorder risk variants, Molecular Psychiatry, 2020, 25(9): 1926-1945.

(3) Shiwu Li^#, Jiao Li^#, Jiewei Liu^#, Junyang Wang, Xiaoyan Li, Yongxia Huo, Yifan Li, Yixing Liu, Ming Li, Xiao Xiao, Xiongjian Luo*. Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression, Brain, 2022, 145(2): 770-786.

(4) Shiwu Li^#, Changguo Ma^#, Yifan Li^#, Rui Chen^#, Yixing Liu^#, Li Pear Wan^#, Qiuxia Xiong, Chuang Wang, Yongxia Huo, Xinglun Dang, Yongfeng Yang, Luxian Lv, Xi Chen, Nengyin Sheng*, Wenqiang Li*, Xiongjian Luo*. The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density, Translational Psychiatry, 2022, 12(1): 361.

(5) Yifan Li^#, Changguo Ma^#, Shiwu Li^#, Junyang Wang, Wenqiang Li, Yongfeng Yang, Xiaoyan Li, Jiewei Liu, Jinfeng Yang, Yixing Liu, Kaiqin Li, Jiao Li, Di Huang, Rui Chen, Luxian Lv, Xiao Xiao, Ming Li, Xiongjian Luo*. Regulatory variant rs2535629 in ITIH3 intron confers schizophrenia risk by regulating CTCF binding and SFMBT1 expression, Advanced Science, 2022, 9(6): 2104786.

(6) Yifan Li^#, Shiwu Li^#, Jiewei Liu, Yongxia Huo, Xiongjian Luo*. The schizophrenia

susceptibility gene NAGA regulates dendritic spine density: further evidence for the dendritic

spine pathology of schizophrenia, Molecular Psychiatry, 2021, 26(12): 7102-7104.

(7) Jingmei Zhong^#, Shiwu Li^#, Wanli Zeng^#, Xiaoyan Li^#, Chunjie Gu, Jiewei Liu, Xiongjian Luo*. Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder, Neuropsychopharmacology, 2019, 44(9): 1542-1551.

(8) Yan Zhang^#, Shiwu Li^#, Xiaoyan Li^#, Yongfeng Yang, Wenqiang Li, Xiao Xiao, Ming Li, Luxian Lv*, Xiongjian Luo*. Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene, Journal of Medical Genetics, 2020, 58(10): 666-678.

(9) Yan Zhang^#, Chuyi Zhang^#, Shiwu Li^#, Jing Yuan, Li Xu, Yujun Wei, Fang Zhou, Junyang Wang, Jinhua Huo, Lu Wang, Limei Feng, Chuanyuan Kang*, Jianzhong Yang*. A functional population-specific variant rs77416373 in the CaV2.1 gene is associated with antidepressant treatment response in Han Chinese subjects with major depressive disorder, Asian Journal of Psychiatry, 2022, 77: 103272.

(10) Shiwu Li, Xiaoyan Li, Jiewei Liu, Yongxia Huo, Long Li, Junyang Wang, Xiongjian Luo*. Functional variants fine-mapping and gene function characterization provide insights into the

role of ZNF323 in schizophrenia pathogenesis, American Journal of Medical Genetics Part B-

Neuropsychiatric Genetics, 2021, 186(1): 28-39.

(11) Jiewei Liu, Shiwu Li, Xiaoyan Li, Wenqiang Li, Yongfeng Yang, Suqin Guo, Luxian Lv, Xiao Xiao, Yonggang Yao, Fanglin Guan, Ming Li, Xiongjian Luo*. Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia, BMC Medicine, 2021,19(1): 177.

(12) Junyang Wang, Shiwu Li, Xiaoyan Li, Jiewei Liu, Jinfeng Yang, Yifan Li, Wenqiang Li, Yongfeng Yang, Jiao Li, Rui Chen, Kaiqin Li, Di Huang, Yixing Liu, Luxian Lv, Ming Li, Xiao Xiao, Xiongjian Luo*. Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1, Brain, 2022, 145(7): 2569-2585.

(13) Junyang Wang, Jiewei Liu, Shiwu Li, Xiaoyan Li, Jinfeng Yang, Xinglun Dang, Changgai Mu, Yifan Li, Kaiqin Li, Jiao Li, Rui Chen, Yixing Liu, Di Huang, Zhijun Zhang, Xiong Jian Luo*. Genetic regulatory and biological implications of the 10q24.32 schizophrenia risk locus, Brain,2022, 146: 1403-1419.

(14) Rui Chen^#, Jiewei Liu^#, Shiwu Li, Xiaoyan Li, Yongxia Huo, Yonggang Yao, Xiao Xiao, Ming Li, Xiongjian Luo*. Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants, BMC Medicine, 2022, 20(1): 68.

(15) Weipeng Liu^#, Hao Yan^#, Danyang Zhou^#, Xin Cai^#, Yuyanan Zhang, Shiyi Li, Huijuan Li, Shiwu Li, Dongsheng Zhou, Xingxing Li, Chen Zhang, Yan Sun, Jia-Pei Dai, Jingmei Zhong, Yonggang Yao, Xiongjian Luo, Yiru Fang, Dai Zhang, Yina Ma, Weihua Yue*, Ming Li*, Xiao Xiao*. The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population, Translational Psychiatry, 2019, 9: 333.

(16) Kaiqin Li, Yifan Li, Junyang Wang, Yongxia Huo, Di Huang, Shiwu Li, Jiewei Liu, Xiaoyan Li, Rong Liu, Xiaogang Chen, Yonggang Yao, Ceshi Chen, Xiao Xiao, Ming Li*, Xiongjian Luo*. A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population, Journal of Genetics and Genomics, 2020, 47(5): 233-248.

(17) Yifan Li, Changguo Ma, Wenqiang Li, Yongfeng Yang, Xiaoyan Li, Jiewei Liu, Junyang Wang, Shiwu Li, Yixing Liu, Kaiqin Li, Jiao Li, Di Huang, Rui Chen, Luxian Lv, Ming Li, Xiongjian Luo*. A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression, Molecular Psychiatry, 2021, 26(11): 6896-6911.

(18) Zhi-Hui Yang^#, Xin Cai^#, Zhong-Li Ding^#, Wei Li^#, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang*, Hong Chang*, Xiao Xiao*. Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function, BMC Medicine, 2023, 21(1): 254.

(19) Mei-Yu Yin^#, Lei Guo^#, Li-Juan Zhao^#, Chen Zhang*, Wei-Peng Liu, Chu-Yi Zhang, Jin-Hua Huo, Lu Wang, Shi-Wu Li, Chang-Bo Zheng, Xiao Xiao, Ming Li*, Chuang Wang*, Hong Chang*. Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice, BMC Medicine, 2023, 21(1): 256.