简历

主要从事非人灵长类感染性疾病模型构建及机制相关研究。目前，已成功构建SIVmac239、SARS-CoV-2、Zika等感染的恒河猴、北平顶猴实验动物模型；开发了肠道切除吻合术活体取材方案、基于恒河猴脑组织多脑区精细分割解剖方案、鼻饲长期给药评估方案等。首次明确了糖代谢异常是HIV感染者生精功能障碍的重要诱因；发现了氧化应激在SIVmac239感染恒河猴急性期黏膜屏障损伤方面的重要作用；阐述了生理性小胶质细胞高活化状态诱导SIV感染恒河猴深部合团损伤的潜在机制；分析了老年恒河猴新冠感染后肺部延迟但更为严重的免疫风暴特征；评估了北平顶猴模型作为新冠重症模型的应用价值。已在Cell Research、Nature Communications、Cell Discovery、Science China Life Sciences、Frontiers in Endocrinology等期刊，以第一作者/共同第一作者身份发表SCI论文16篇。参与完成的3个SARS-CoV-2疫苗获批上市。获得中华人民共和国科学技术部颁发的“全国科技系统抗击新冠肺炎疫情先进个人”奖励。

学习和工作经历

2022/1-至今, 中国科学院昆明动物研究所，副研究员

2020/1-2022/1, 中国科学院昆明动物研究所，助理研究员

2016/9-2020/1, 中国科学院昆明动物研究所, 免疫学, 博士

2013/9-2016/6, 中山大学，病原生物学, 硕士

2008/9-2013/7, 山东中医药大学，中西医临床医学, 学士

非人灵长类感染性疾病模型构建及机制研究

82202508  oxLDL/CD36通路在SIV感染猕猴急性期脑区损伤差异中的作用及机制研究

2022-01~2025-12  30万  国家自然科学基金青年项目 主持

202201AU070122  SIV感染中国猕猴活动性结核期组织病毒库及免疫活化特征研究

2022-06~2025-05  5万元 云南省青年人才项目 主持

全国科技系统抗击新冠肺炎疫情先进个人

1. Song TZ#, Han JB#, Yang X#, Li MH, Zheng YT*. Tissue distribution of SARS-CoV-2 in non-human primates after combined intratracheal and intranasal inoculation. Sci China Life Sci, 2021, 64(10):1792-1794.

2. Song TZ, Zhang MX, Zhang HD, Wang XH, Pang W, Tian RR, Zheng YT*. Glucose metabolism disorder induces spermatogenic dysfunction in northern pig-tailed macaques (Macaca leonina) with long-term SIVmac239 infection. Front Endocrinol, 2021, Sept 24, 12: 745984.

3. Song TZ, Zheng YT*. Monkeypox, wild animals, and potential big problem. Zool Res, 2022, 43(4):612-614.

4. Song TZ#, Zheng HY#, Han JB#, Jin L#, Yang X, Liu FL, Luo RH, Tian RR, Cai HR, Feng XL, Liu C. Li MH, Zheng YT*. Delayed severe cytokines storm and immune cells infiltration in SARS-CoV-2 infected aged Chinese rhesus macaques. Zool Res, 2020, 41(5): 503-516.

5. Song TZ, Zhang MX, Zhang HD, Xiao Y, Pang W, Zheng YT*. Comparison of HIV status between transgender women and men who have sex with men: A meta-analysis. J Assoc Nurses AIDS Care. 2018, 29(5):681-697. DOI: 10.1016/j.jana.2018.04.001.

6. Song TZ#, Zhang MX#, Xia YJ, Xiao Y, Pang W, Zheng YT*. Parasites may exit immune-compromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239. Zool Res. 2018, 39 (1): 42-51.

7. Song TZ, Zhang HD, Zuo Z, Zheng YT*. Successful implementation of intestinal endoscopy in non-human primates prompts the possibility of achieving AIDS longitudinal intestinal researches. J Med Primatol, 2019, Jun; 48(3):176-178. doi: 10.1111/jmp.12404.

8. Song TZ#, Zheng HY#, Han JB#, Feng XL, Liu FL, Yang X, Jin L, Luo RH, Tian RR, Liu C, Li MH, Cai HR, Zheng YT*. Northern pig-tailed macaques (Macaca leonina) infected with SARS-CoV-2 show rapidly viral clearance and persistent immune response. Zool Res, 2021, May 18, 42(3):350-353.

9. Sun S#, Cai Y#, Song TZ#, Pu Y#, Cheng L, Xu H, Sun J, Meng C, Lin Y, huang H, Zhao F, Zhang S, Gao Y, Han JB, Feng XL, Yu DD, Zhu Y, Gao P, Tang H, Zhao J, Zhang Z, Yang J, Hu Z, Fu YX*, Zheng YT*, Peng H*. Interferon-armed RBD dimer enhances immunogenicity of RBD for sterilizing immunity against SARS-CoV-2. Cell Res, 2021, Sep; 31(9):1011-1023.

10. Long Y#, Sun J#, Song TZ#, Liu T#, Tang F#, Zhang X#, Ding L#, Miao Y, Zhu W, Pan X, An Q, Qin M, Tong X, Peng X, Yu P, Zhu P, Xu J, Zhang X, Zhang Y, Liu D, Chen B, Chen H, Zhang L, Xiao G, Zuo J, Tang W, Zhou J, Li H, Xu Z, Zheng HY, Long XY, Qin Q*, Gan Y*, Ren J*, Huang W*, Zheng YT*, Jin G*, Gong L*. CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity. Cell Discov, 2022, Feb 1; 8(1):9.

11. Liang JG#, Su D#, Song TZ#, Zeng Y#, Huang W#, Wu J, Xu R, Luo P, Yang X, Zhang X, Luo S, Liang Y, Li X, Huang J, Wang Q, Huang X, Xu Q, Luo M, Huang A, Luo D, Zhao C, Yang F, Han JB, Zheng YT, Liang P*. S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates. Nat Commun, 2021; Mar 1; 12(1):1346.

12. Zhang MX#, Song TZ#, Zheng HY, Wang XH, Lu Y, Zhang HD, Li T, Pang W, Zheng YT*. Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina). Zool Res, 2019, 40(6):522-531.

13. Wang XH, Song TZ, Li L, Tian RR, Zheng YT*. Successful implementation of intestinal resection and anastomosis in non-human primates suggests the possibility of longitudinal intestinal research. Zool Res, 2020, 41(4): 449-454.

14. Wang XH, Song TZ, Zheng HY, Li YH, Zheng YT*. Jejunal epithelial barrier disruption triggered by reactive oxygen species in early SIV infected rhesus macaques. Free Radic Biol Med, 2021, Oct 20; 177:143-155.