简历

王林，男，博士，副研究员。从事多能干细胞的基因组稳定性调控机理研究，鉴定了一系列多能干细胞特异的维持基因组稳定性的因子，包括长链非编码RNA和蛋白因子。相关研究结果以第一作者（含并列）在Nature Communications、Science Advances、PANS等国际期刊发表多篇SCI论文。主持国家自然科学基金青年基金、云南省面上项目和云南省重点项目，入选云南省“兴滇英才支持计划”青年人才。 

学习和工作经历

2022. 01-现在 中国科学院昆明动物研究所，哺乳动物胚胎发育学科组，副研究员 

2015. 09-2021.12 中国科学院昆明动物研究所，哺乳动物胚胎发育学科组，助理研究员 

2011. 09-2015.9 清华大学，干细胞与再生医学中心，博士后 

2006. 09-2011.7 北京协和医学院，获博士学位 

2001. 09-2005.06 云南大学生命科学学院，获学士学位

多能干细胞是一类具有自我更新和无限增殖能力的多潜能细胞，包括胚胎干细胞和诱导多能干细胞，可在体外分化为各类细胞和类器官用于药物测试研发、模拟体内发育的过程，在再生医学中作为种子细胞用于临床细胞治疗，具有巨大的应用前景。然而，多能干细胞在长期的培养过程中，遗传物质容易发生变异，这极大地阻碍了多能干细胞的实际应用。针对这个问题，我们拟从多个角度解析多能干细胞的基因组稳定性调控机理，优化多能干细胞的培养条件，实现多能干细胞的长期稳定培养。

1. 胚胎干细胞特异基因Dppa5通过可变剪接调控基因组稳态的分子机制研究， 2023.06-2026.6， 50万元，云南省科技厅，重点项目，主持 

2. 云南省“兴滇英才支持计划”青年人才专项，2023.01-2027.12，50万元，云南省社会资源和社会保障厅，主持 

3. 中国科学院西部之光，2023.01-2025.12，50万元，中国科学院，主持 

以第一/共同第一作者身份发表论文:

1.Huaixiao Ma#, Yuqi Ning#, Lin Wang#, Weidao Zhang, Ping Zheng*. Lnc956 regulates mouse embryonic stem cell differentiation in response to DNA damage in a p53-independent pathway. Science Advances. 2023; 9(3):eade9742. 

2.Fangjie Jiang#, Lin Wang#, Yuping Dong, Wenhui Nie, Hu Zhou , Jing Gao, and Ping Zheng*. DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of Rev1 and Polq in mouse embryonic stem cells. Proceedings of the National Academy of Sciences. 2023;120(30):e2305187120.

3.Lin Wang#, Jingzheng Li#, Hu Zhou, Weidao Zhang, Jing Gao & Ping Zheng*. A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability. Nature Communications. 2021; 12:5572.

4. Lin Wang#, Fengzhi Zhang#, Fuyu Duan, Rujin Huang, Xi Chen, Jia Ming and Jie Na*. Homozygous MESP1 knock-in reporter hESCs facilitated cardiovascular cell differentiation and myocardial infarction repair. Theranostics. 2020; 10 (15): 6898-6913.

以合作者身份发表论文:

1. Weidao Zhang#, Min Tang#, Lin Wang, Hu Zhou, Jing Gao, Zhongliang Chen, Bo Zhao*, Ping Zheng*. Lnc956-TRIM28-HSP90B1 complex on replication forks promotes CMG helicase retention to ensure stem cell genomic stability and embryogenesis. Science Advances. 2023; 9(4):eadf6277.

2. Daohua Gong, Lin Wang, Hu Zhou, Jing Gao, Weidao Zhang, and Ping Zheng*. Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells. Stem Cell Reports. 2023;18(4):952-968.

3. Jingzheng Li, Yafang Shang, Lin Wang, Bo Zhao, Chunli Sun, Jiali Li, Siling Liu, Cong Li, Min Tang, Fei-Long Meng*, Ping Zheng*. Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia. Science Advances. 2020; 6: eaba0682.

4. Fengzhi Zhang, Yonglin Zhu, Jing Chen, Wenhua Kuang, Rujin Huang, Fuyu Duan, Yaqian Li, Lin Wang, Hui Qiu, Xia Chen, Jia Ming, Peng Liu, Yanan Du, Sophia Chia-Ning Chang, Ligong Chen, Jie Na*. Efficient endothelial and smooth muscle cell differentiation from human pluripotent stem cells through a simplified insulin-free culture system. Biomaterials. 2021; 271:120713.

5. Huaixiao Ma#, Jinglei Zhai#, Haifeng Wan#, Xiangxiang Jiang#, Xiaoxiao Wang, Lin Wang, Yunlong Xiang, Xiechao He, Zhen-Ao Zhao, Bo Zhao, Ping Zheng*, Lei Li*, Hongmei Wang*. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science. 2019; 366(6467):eaax7890.

6. Xiangxiang Wei#, Jieyu Guo*, Qinhan Li, Qianqian Jia, Qing Jing, Yan Li, Bin Zhou, Jiayu Chen, Shaorong Gao, Xinyue Zhang, Mengping Jia, Cong Niu, Wenlong Yang, Xiuling Zhi, Xinhong Wang, Dian Yu, Lufeng Bai, Lin Wang, Jie Na, Yunzeng Zou, Jianyi Zhang, Shuning Zhang*, Dan Meng*. Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells. Science Advances. 2019;5(3): eaau7887.

7. Fuyu Duan, Rujin Huang, Fengzhi Zhang, Yonglin Zhu, Lin Wang, Xia Chen, Lufeng Bai, Wei Guo, Sophia Chia-Ning Chang, Xiaoyu Hu and Jie Na*. Biphasic modulation of insulin signaling enables highly efficient hematopoietic differentiation from human pluripotent stem cells. Stem Cell Research & Therapy. 2018;9 (1):205.

8. Xi Chen, Lin Wang, Rujin Huang, Hui Qiu, Peizhe Wang, Daren Wu, Yonglin Zhu, Jia Ming, Yangming Wang, Jianbin Wang, Jie Na*. Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program. Protein & Cell. 2018;10(5) :327-346.

9. Fengzhi Zhang, Lin Wang, Yaqian Li, Wei Liu, Fuyu Duan, Rujin Huang, Xi Chen, Sophia Chia-Ning Chang,Yanan Du and Jie Na*. Optimizing mesoderm progenitor selection and three-dimensional microniche culture allows highly efficient endothelial differentiation and ischemic tissue repair from human pluripotent stem cells. Stem Cell Research & Therapy. 2017; 8(1):6.

Chao-Hui Li, Lan-Zhen Yan, Wen-Zan Ban, Qiu Tu, Yong Wu, Lin Wang, Rui Bi, Shuang Ji,Yu-Hua Ma, Wen-Hui Nie, Long-Bao Lv, Yong-Gang Yao*, Xu-Dong Zhao*, Ping Zheng*. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring. Cell Research. 2016;27(2): 241-252.