承担科研项目:
中科院先导专项“动物复杂性状的进化解析与调控”,XDB13030100,脂肪储存水平与代谢率适应性的进化,2014/06-2019/12,550万,在研,课题负责人;
中科院"王宽诚率先人才计划卢嘉锡国际团队",热量限制影响衰老研究团队,2018/01-2020/12,300万,在研,团队负责人;
国家自然科学基金重大研究计划“微进化过程的多基因作用机制”集成项目,91731303,不同时期遗传混合对东亚、东南亚等地区人群基因多样性的影响及其适应机制,2018/01-2019/12,100万,在研,项目参与人;
国家自然科学基金重大研究计划培育“器官衰老与器官退行性变化的机制”培育项目,91649108,下丘脑饥饿信号通路在热量限制抗肝脏衰老中的作用研究,2017/01-2019/12,60万,在研,项目负责人;
国家自然科学基金面上项目,31570410,高原鼠兔受海拔影响体型进化(贝格曼定律)的选择基础,2016/01-2019/12,63万,在研,项目负责人;
中科院对外国际合作重点项目,GJHZ1660,决定亚洲成年人身体活动性水平的遗传和环境因素,2016/01-2018/12,100万,在研,项目负责人;
国家自然科学基金重大研究计划“微进化过程的多基因作用机制”培育项目,91431102,人类基因组体重调控相关基因位点的选择信号:对“节俭基因”假说的验证,60万,2015/01-2015/12,结题,项目负责人;
2011-2016,能量平衡调控,已结题,项目负责人。
学术任职:
2011-至今,《Science》(美国)(SCI收录),编委
2012-至今,《Molecular Metabolism》(荷兰)(SCI收录),编委,创刊人之一
2002 -至今,《Mammal review》(英国)(SCI收录),编委
2004-2007,《Aging Cell》(英国)(SCI收录),学科编辑
2004-至今,《Journal of Comparative Physiology》(德国)(SCI收录),编委
2004-2009,《Functional Ecology》(英国)(SCI收录),编委
2008-至今,《Biology letters》(英国)(SCI收录),编委
2011-至今,《Biology Open》(英国)(SCI收录),副总编,编委
2012-至今,《IUBMB Life》(英国)(SCI收录),编委
2013-至今,《Journal of Genetics and Genomics》(中国)(SCI收录),编委
2015-至今,《Physiological and Biochemical zoology》(美国)(SCI收录),编委
主要从事能量平衡领域的研究,揭示能量平衡的调控因素及其对衰老和肥胖等的影响等。
1) Wang G,Speakman John R. Analysis of positive selection at single nucleotide polymorphisms associated with body mass index does not support the “Thrifty Gene” hypothesis. Cell Metabolism, 2016, 24(4): 531-541.
2) Nie Y#,Speakman JR#, Wu Q#, et al. Exceptionally low daily energy expenditure in the bamboo-eating giant panda. Science, 2015, 349(6244): 171-174.
3) Scantlebury DM, Mills MGL, Wilson RP, Wilson JW, Mills MEJ, Durant SM, Bennett NC, Bradford P, Marks NJ,Speakman JR.Flexible energetics of cheetah hunting strategies provide resistance against kleptoparasitism. Science, 2014, 346(6205): 79-81.
4) Tschop MH#,Speakman JR#, Arch JRS,et al.A guide to analysis of mouse energy metabolism. Nature Methods, 2012, 9(1): 57-63.
5) Speakman, JR.A nonadaptive scenario explaining the genetic predisposition to obesity: the "predation release" hypothesis. Cell Metabolism, 2007, 6(1): 5-12.
6) Scantlebury M,Speakman JR, Oosthuizen MK, Roper TJ, Bennett NC. Energetics reveals physiologically distinct castes in a eusocial mammal. Nature, 2006, 440(7085): 795-797.
7) Speakman JR, Ergon T, Cavanagh R, Reid K, Scantlebury DM, Lambin X. Resting and daily energy expenditures of free-living field voles are positively correlated but reflect extrinsic rather than intrinsic effects. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100(24): 14057-14062.
8) Humphries MM, Thomas DW,Speakman JR,2002. Climate-mediated energetic constraints on the distribution of hibernating mammals. Nature, 418(6895), 313-316.
9) Thomas DW, Blondel J, Perret P, Lambrechts MM,Speakman JR.Energetic and fitness costs of mismatching resource supply and demand in seasonally breeding birds. Science, 2001, 291(5531): 2598-2600.
10)Gorman ML, Mills MG, Raath JP,Speakman JR.High hunting costs make African wild dogs vulnerable to kleptoparasitism by hyaenas. Nature, 1998, 391(6666): 479-481.
11) Speakman JR, Racey PA. No cost of echolocation for bats in flight. Nature, 1991, 350(6317):