承担科研项目:
国家重点研发计划蛋白质机器与生命过程调控,2017YFA0506400,
跨细胞蛋白质内稳态调控机制, 2017/07-2022/06, 500万,在研,项目负责人
国家自然科学基金面上项目,31771333,发育时期线粒体应激诱导长寿的表观调控机理研究,2008/01-2021/12,60万元,在研,项目负责人
主要从事线粒体功能调控衰老领域的研究
Berendzen, K.M., Durieux, J., Shao, L.-W., Tian, Y., Kim, H., Wolff, S., Liu, Y., and Dillin, A. (2016). Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis. Cell 166, 1553–1563.e10.
Tian, Y., Merkwirth, C., and Dillin, A. (2016). Mitochondrial UPR: A Double-Edged Sword. Trends in Cell Biology 26, 563–565.
Tian, Y., Garcia, G., Bian, Q., Steffen, K., Joe, Larry., Wolff, S., Meyer, B.J., and Dillin, A. (2016) Mitochondrial stress induces chromatin reorganization to promote longevity and UPRmt. Cell 165, 197-208
Russell, R.C., Tian, Y., Yuan, H., Park, H.W., Chang, Y.-Y., Kim, J., Kim, H., Neufeld, T.P., Dillin, A., and Guan, K.-L. (2013). ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat. Cell Biol. 15, 741–750.
Tian, Y*., Li, Z*., Hu, W*., Ren, H*., Tian, E., Zhao, Y., Lu, Q., Huang, X., Yang, P., Li, X., et al. (2010a). C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell 141, 1042–1055. (*equal contribution)
Tian, Y., Ren, H., Zhao, Y., Lu, Q., Huang, X., Yang, P., and Zhang, H. (2010b). Four metazoan autophagy genes regulate cargo recognition, autophagosome formation and autolysosomal degradation. Autophagy 6, 984–985.
Tian, Y., Garcia, G., Bian, Q., Steffen, K., Joe, Larry., Wolff, S., Meyer, B.J., and Dillin, A. (2016) Mitochondrial stress induces chromatin reorganization to promote longevity and UPRmt. Cell 165, 197-208
Tian, Y*., Li, Z*., Hu, W*., Ren, H*., Tian, E., Zhao, Y., Lu, Q., Huang, X., Yang, P., Li, X., et al. (2010a). C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell 141, 1042–1055. (*equal contribution) |