| 论文题目: | CircGRIA1 Shows an Age-related Increase in Male Macaque Brain and Regulates Synaptic Plasticity and Synaptogenesis |
| 作者: | Xu K, Zhang Y, Xiong W, Zhang Z, Wang Z, Lv L, Liu C, Hu Z, Zheng YT, Lu L, Hu XT, Li J |
| 联系作者: | jialili@bjmu.edu.cn |
| 发表年度: | 2020 |
| DOI: | doi: 10.1038/s41467-020-17435-7 |
| 摘要: | Circular RNAs (circRNAs) are abundant in mammalian brain and some show age-dependent expression patterns. Here, we report that circGRIA1, a conserved circRNA isoform derived from the genomic loci of α-mino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor subunit Gria1, shows an age-related and male-specific increase in expression in the rhesus macaque prefrontal cortex and hippocampus. We show circGRIA1 is predominantly localized to the nucleus, and find an age-related increase in its association with the promoter region of Gria1 gene, suggesting it has a regulatory role in Gria1 transcription. In vitro and in vivo manipulation of circGRIA1 negatively regulates Gria1 mRNA and protein levels. Knockdown of circGRIA1 results in an age-related improvement of synaptogenesis, and GluR1 activity-dependent synaptic plasticity in the hippocampal neurons in males. Our findings underscore the importance of circRNA regulation and offer an insight into the biology of brain aging |
| 刊物名称: | Nature Communications |
| 论文出处: | https://www.nature.com/articles/s41467-020-17435-7 |
| 影响因子: | 12.121(2019年) |
