1.国家重点研发计划，2023YFC3603304，2023-2026，课题负责人

2.国家自然科学基金面上项目，82471599，2025-2028，主持

3.国家自然科学基金面上项目，82171558，2022-2025，主持

4.国家自然科学基金面上项目，81671404，2017-2020，主持

5.国家自然科学基金青年项目，81500670，2016-2018，主持

6.中国科学院战略性先导科技专项（A类），2018-2023，课题负责人

7.国家重点研发计划项目，2013CB530802，2013-2017，课题骨干

近5年内发表的代表性论文/专著（^*通讯作者，^#共同第一作者）

1.  Dong X^#, Zhou Z^#, Wang YN^#, Nisar A, Pu SY, Lv LB, Li YJ, Lu XM*, He YH*. CircAge: A Comprehensive Resource for Aging-Associated Circular RNAs Across Species and Tissues. Genomics, Proteomics & Bioinformatics. 2025 (Accepted)

2.   Gold NM^#, Ding QC^#, Yang Y^#, Pu SY, Cao WJ, Ge XX, Yang PY, Okeke MN, Nisar A, Pan YZ, Luo QN, Wang XY, Xu H, Tian R, Zi MT, Zhang XJ, Li ST*, He YH*. Therapeutic Potential of Nicotinamide and ABT263 in Alcohol-Associated Liver Disease through Targeting Cellular Senescence. MedComm. 2025; doi:10.1002/mco2.70086.

3.  Samarawickrama PN^#, Zhang GQ^#, Zhu EF, Dong X, Nisar A, Zhu H, Ma Y, Zhou ZY, Yang HL, Gui L, Cao M, Li W, Chang Y, Zi MT, Cui HL, Duan ZP, Zhang X, Li W*, He HY*. Clearance of senescent cells enhances skin wound healing in type 2 diabetic mice. Theranostics. 2024; 10.7150/thno.100991.

4.   Hu L^#, Dong CJ^#, Wang Z, He SY, Yang YW, Zi MT, Li HQ, Zhang YH, Chen CJ, Zheng RZ, Jia ST, Liu J, Zhang X*, He YH*. A rationally designed fluorescence probe achieves highly specific and long-term detection of senescence in vitro and in vivo. Aging Cell. 2023; doi: 10.1111/acel.13896.

5.  He YH, Koch R, Budamagunta V, Zhang PY, Zhang X, Khan S, Thummuri D, Ortiz YT, Zhang X, Lv DW, Wiegand JS, Li W, Palmer AC, Zheng GR, Weinstock D. M*, Zhou DH*. DT2216–a Bcl-xL specific degrader is highly active against Bcl-xL-dependent T-cell lymphomas. Journal of Hematology & Oncology. 2020;13(1):95.

其他代表性论文/专著

1.    Nisar A^#, Sawar K^#, Li W, Hu L, Samarawickrama PN, Gold NM, Zi MT, Mehmood SA, Miao JR, He YH*. Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targets. MedComm. 2024;5(11):e786.

2.    He YH^#, Zhang X^#, Chang JH^#, Kim H^#, Zhang PY, Wang YY, Khan Sajid, Liu XG, Zhang X, Lv DW, Li W, Thummuri D, Yuan YX, Elisseeff J, Campisi J, Almeida M, Song L, Zheng GR*, Zhou DH*. Using Proteolysis-Targeting Chimera Technology to Reduce Navitoclax Platelet Toxicity and Improve Its Senolytic Activity. Nature Communications. 2020;11(1):1996.

3.    He YH, Wen Li, Lv DW, Zhang X, Zhang X, Campisi J, Zheng GR, Zhou DH*. Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. Aging Cell. 2020; 19(3):e13117.

4.    He YH^#, Khan S^#, Huo ZG, Lv DW, Zhang X, Liu XG, Yuan YX, Hromas R, Xu MJ, Zheng GR, Zhou DH. Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies. Journal of Hematology & Oncology. 2020;13(1):103.

5.   He YH, Zheng GR, Zhou DH. Senolytic Drug Development. In: Senolytics in Disease, Ageing and Longevity. Healthy Ageing and Longevity. Springer, Cham. 2020; 11. doi: 10.1007/978-3-030-44903-2_1.